The comparison of three drugs, Ondnasetrone, Dexametasonel and Magnesium Sulfate

Comparing the effect of dexamethasone, ondansetron and magnesium sulfate on post operation shivering in general anesthesia after orthopedic surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012100510340N7

Enrollment

Registered

2012-11-13

Start date

2010-05-18

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Shivering. Complications of surgical and medical care, not elsewhere classified

Interventions

Intervention 1: 8 mg dexamethasone IV. Intervention 2: 8 mg Ondanstrone IV. Intervention 3: 30 mg/kg Magnesium Sulfate IV.

Treatment - Drugs

8 mg dexamethasone IV

8 mg Ondanstrone IV

30 mg/kg Magnesium Sulfate IV

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: age of 18 to 55 years; ASA1, 2; none shivering before surgery. Exclusion Criteria: Hypertension; allergies to medicines, ondasetrone, sufentanil, and magnesium sulfate; Drug addiction; cerebrovascular disease.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Shivering. Timepoint: after surgery. Method of measurement: observation.	—

Secondary

Measure	Time frame
Pain. Timepoint: after surgery. Method of measurement: VAS (Visual Analog Scale).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKazem Kazem nejad

anesthesiology Community

kazenejad1341@yahoo.com+98 17 1442 1651

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026