coronary artery disease. Atherosclerotic heart disease
Conditions
Interventions
Intervention 1: Allopurinol 600 mg orally will be given to intervention group in two separated doses: first dose will be given one day before PCI and second dose given in the day of PCI. Intervention
Treatment - Drugs
Allopurinol 600 mg orally will be given to intervention group in two separated doses: first dose will be given one day before PCI and second dose given in the day of PCI.
Placebo orally will be given to control group in two separated doses: first dose will be given one day before PCI and second dose given in the day of PCI.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients who are candidates for elective PCI. Exclusion criteria: patients who are candidates for CABG or Primary PCI; Glomerular filtration rate less than 60 ml / min or serum creatinine more than 3 mg / dl; history of gout; taking allopurinol; severe liver disease; concomitant use of azathioprine, 6 - mercaptopurine or warfarin.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CTnT. Timepoint: before of intervention, one day after intervention. Method of measurement: ng/ml.;CKMB. Timepoint: before of intervention, one day after intervention. Method of measurement: ng/ml. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Javad Alemzadeh-Ansari
Tehran Heart Center Hospital
Outcome results
None listed