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Evaluation of Levothyroxin therapy on Oxidant and anti Oxidant level in subclinical hypothyroid patients

comparison of oxidant and anti oxidant level after levothyroxin therapy between subclinical hypothyroid patients and normal group

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20121001010980N4
Enrollment
30
Registered
2020-05-28
Start date
2016-04-04
Completion date
Unknown
Last updated
2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

subclinical hypothyroidism. Other specified hypothyroidism

Interventions

Intervention 1: Intervention group: Levothyroxine tablet treatment intervention group with 50 micrograms once daily orally for 3 months (Iran Hormone Company 2). Intervention 2: Control group: In thi

Sponsors

Endocrinology and Metabolism Research Institute
Lead Sponsor

Eligibility

Sex/Gender
All
Age
17 Years to 42 Years

Inclusion criteria

Inclusion criteria: age=17-42 5=10 NORMAL TotalT4

Exclusion criteria

Exclusion criteria: Smoking alcohol consumption Pregnancy and pregnancy intent Sodium levothyroxine consumption lipid lowering drugs Anti hypertensive drugs Taking vitamin supplements that affect the state of oxidative stress History of diabetes Mellitus - History of cardiovascular disease History of liver disease History of kidney disease

Design outcomes

Primary

MeasureTime frame
Oxidant-Antioxidant balance. Timepoint: before intervention and 12 weeks after levothyroxin therapy. Method of measurement: serum sample.By the method of measuring prooxidant-antioxidant balance.Measurement of light spectrum by Eliza reader.;Hs-CRP. Timepoint: before intervention and 12 weeks after levothyroxin. Method of measurement: serum sample.Immunoturbidometry assay with commercial kit.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNooshin Shirzad

Tehran University of Medical Sciences

nshirzad11@gmail.com0098 21 ?????

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026