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The effect of the combination of vitex agnus castus`s phytoestrogen and magnesium on fracture healing.

The effect of the combination of vitex agnus castus`s phytoestrogen and magnesium on serum alkaline phosphatase, osteocalcin, angiogenic factor and bone repair in 20-45-year-old wemen with long bone fracture.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2012092810955N1
Enrollment
64
Registered
2012-10-29
Start date
2012-04-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Fracture of shaft of femur. Condition 2: Fracture of shaft of tibia. Condition 3: Fracture of shaft of humerus. Condition 4: Fracture of shafts of both ulna and radius. Fracture of shaft of femur Fracture of shaft of tibia Fracture of shaft of humerus Fracture of shafts of both ulna and radius

Interventions

Intervention 1: vitex agnus castus supplements intake is equivalent to 3.2-4.8 mg fruit dry extract per day, for 2 months. Intervention 2: Magnesium supplements, 250 mg magnesium per day, for 2 months
Treatment - Drugs
Placebo
vitex agnus castus supplements intake is equivalent to 3.2-4.8 mg fruit dry extract per day, for 2 months
Magnesium supplements, 250 mg magnesium per day, for 2 months
placebo tablet, per day, for 2 months
vitex agnus castus supplements intake is equivalent to 3.2-4.8 mg fruit dry extract per day, for 2 months and Magnesium supplements, 250 mg magnesium per day, for 2 months

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Women with fracture in long bone (femur, tibia, humerus, radius or ulna); 20-45-year-old. Exclusion criteria: Pregnant or lactating; postmenopausal women; medications for any chronic disease (cancer, diabetes, CVD); use of medication known to affect bone metabolism; use of herbal drug contain phytoestrogen, use of supplements ( multivitamin-minerals,...), diuretics, hormonal drugs; Smoking; Alcohol consumption.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Serum Alkaline phosphatase. Timepoint: Before and 2 months after intervention. Method of measurement: Calorimetry method.;Serum Osteocalcin. Timepoint: Before and 2 months after intervention. Method of measurement: ELISA kit.;Serum Vaso Endothelial Growth Factor. Timepoint: Before and 2 months after intervention. Method of measurement: ELISA kit.;Callus formation. Timepoint: Before and 2 months after intervention. Method of measurement: Radiographic Evidence.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Hasanzadeh Rostami

School of Health & Nutrition, Shiraz University of Medical Sciences

hasanzadez@sums.ac.ir hassanzadeh_z8@yahoom.com+98 71 1725 1001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026