Effect of vitamin B12 infusion in prevention of nitrous oxide- induced homocysteine increase

Effect of vitamin B12 infusion in prevention of nitrous oxide- induced homocysteine increase in patients undergoing general anesthesia for elective surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201209226803N3

Enrollment

Registered

2012-09-30

Start date

2012-08-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nitrous oxide in general anesthesia. Poisoning by and exposure to other and unspecified drugs, medicaments and biological substances, undetermined intent

Interventions

Intervention 1: before surgery 1mg Vitamin B12 with 100ml normal saline will be infused, during surgery % 60 nitrous oxide will be prescribed and after end of surgery100ml normal saline will be infus

Treatment - Drugs

Placebo

before surgery 1mg Vitamin B12 with 100ml normal saline will be infused, during surgery % 60 nitrous oxide will be prescribed and after end of surgery100ml normal saline will be infused to patients.

before surgery 100ml normal saline will be infused, during surgery % 60 nitrous oxide will be prescribed and after end of surgery 1mg Vitamin B12 with 100 ml normal saline will be infused to patients

before and after end of surgery 100ml normal saline will be infused and during surgery % 60 nitrous oxide will be prescribed to patients.

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Informed written consent; ASA class ?-??; Age between 18 and 45 years; Elective surgeries that operation time is estimated at more than 2 hours. Exclusion criteria: Pregnancy; Emergency Surgery; Contraindications of nitrous oxide )such as Pneumothorax; Mechanical intestinal obstruction; Occlusion of the middle ear; Laparoscopic Surgery; Laser Surgery; Increased ICP); Intake of vitamin B12 and folate supplements before surgery; Contraindications of vitamin B12 and folate; Leber's disease; Patients with vitamin B12 or folate deficiency; megaloblastic anemia; Anesthesia in the past month; Smoking; Renal failure; hypothyroidism.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Plasma homocysteine. Timepoint: before intervention, 24h after intervention. Method of measurement: blood sampling.	—

Secondary

Measure	Time frame
Nausa and vomiting. Timepoint: after intervention in the end of surgery. Method of measurement: Questionnaire.;Plasma vit B12. Timepoint: before intervention, 24h after intervention. Method of measurement: blood sampling.	—

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026