Opium Addiction. Mental and behavioural disorders due to use of opioids
Conditions
Interventions
Intervention 1: Patients in control group undergo spinal anesthesia with 12.5 mg Bupivacaine (20mg/4ml, manufactured by ICI Pharmaceuticals India Limited) plus 0.5 ml sterile instilled water. Interven
Treatment - Drugs
Patients in control group undergo spinal anesthesia with 12.5 mg Bupivacaine (20mg/4ml, manufactured by ICI Pharmaceuticals India Limited) plus 0.5 ml sterile instilled water
In intervention group spinal anesthesia is performed using 12.5 mg bupivacaine (20mg/4ml, made by ICI Pharmaceuticals India Limited) and 25µg fentanyl (0.5mg/10ml, manufactured by Aburaihan Co.Iran).
Sponsors
Deputy of Research Kerman University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
15 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1) patient's consent of spinal anesthesia. 2) The patient who are admitted for lower abdomen and lower extremity surgery. 3) patients who are in the age range of 65-15 year 4) Patients in the height range between 185 - 150 cm 5)opium addict is a person who have used opium orally or inhales it at least for one year 6) surgery length of 80 to 150 minutes 7) No history of other drug abuse and psychological disorders. 8) Weight between 50 to 85 kg. exclusion criteria: 1- consuming other kinds of drugs 2- history of pulmonary or cardiac diseases 3-history of disorders which have absolute or partial contraindication for spinal anesthesia 4- history of hypersensitivity to fentanyl or bupivacaine.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The onset of pain after surgery. Timepoint: after operation. Method of measurement: asking the patient. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure. Timepoint: every 5 minutes and every 15 minutes in PACU. Method of measurement: digital monitoring device.;The length of sensory nerves block. Timepoint: at 40,50,60,70,80,90,100,110 and 120 minutes. Method of measurement: skin stimulation test.;The length of motor nerves block. Timepoint: at 40,50,60,70,80,90,100,110 and 120 minutes. Method of measurement: asking the patient to move his legs.;The time of onset the analgesia. Timepoint: after performing the procedure. Method of measurement: skin stimulation test.;Nausea and vomiting. Timepoint: throughout the operation and in PACU. Method of measurement: asking the patient.;Itching. Timepoint: throughout the operation and in PACU. Method of measurement: asking the patient.;Shivering. Timepoint: throughout the operation and in PACU. Method of measurement: observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzam Karimi
Kerman University of Medical Sciences
Outcome results
None listed