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The effect of melatonin on endometrial histology in patients with disordered simple hyperplasia.

The effect of melatonin and megestrol acetate compared to megestrol acetate alone on endometrial histology in patients with endometrial proliferative disorders: a double blind randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120922010901N10
Enrollment
40
Registered
2023-05-08
Start date
2023-02-20
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometrial hyperplasia. Endometrial hyperplasia

Interventions

Intervention 1: Control group:Patients in the control group, will be treated with megestrol acetate at a daily dose of 80mg(Aboureihan Pharmaceuticals Iran]). Patients will be observed fo

Sponsors

Vice chancellor for Research,Tabriz University Of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
38 Years to 55 Years

Inclusion criteria

Inclusion criteria: Age of 38 to 55 years Women with abnormal uterine bleeding and proliferative endometrium with irregular glands Willingness to participate in the study BMI between 18.5 and 29.99

Exclusion criteria

Exclusion criteria: Atypical hyperplasia and endometrial cancer diagnosis History of hormone therapy in the last 3 months Not consent to participate in the study Diabetes History of depression and use of antidepressants Coagulation disorders Hypertension Seizures and the use of antiepileptic drugs Having autoimmune diseases

Design outcomes

Primary

MeasureTime frame
Histologic types of endometrium. Timepoint: Three months after the first dose of the drug. Method of measurement: Microscopic examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Parvin Mostafa Gharabaghi

Tabriz University of Medical Sciences

gharabagh.p@tbzmed.ac.ir+98 41 1553 9161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026