Comparative efficacy of different classes of drugs for prevention of shivering after general anesthesia

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201209187686N2

Enrollment

240

Registered

2012-11-13

Start date

2012-06-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abnormal involuntary movements. Abnormal involuntary movements Excl: specific movement disorders , stereotyped movement disorders, tic disorders

Interventions

Intervention 1: The first group consisted of patients who receive intravenous 2 mg/ kg Hydrocortisone ten minutes before the end of surgery. Intervention 2: The second group consisted of patients who

Treatment - Drugs

The third group consisted of patients who received slow IV infusion 2 mg/ kg tramadol 30 minutes before the end of surgery

The fourth group consisted of patients received bolus intravenous 80 mg/ kg magnesium sulfate

The fifth group includes patients that received intravenous injection of 0.4 mg/ kg meperidine before the end of surgery

The first group consisted of patients who receive intravenous 2 mg/ kg Hydrocortisone ten minutes before the end of surgery

The second group consisted of patients who received intravenous 0.5 mg/ kg ketamin 20 minutes before the end of surgery

The sixth group consisted of patients that revived intravenous 10 to 15 ml/ per kg of normal saline isothermal to the operating room during surgery

Eligibility

Sex/Gender

All

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: all patients undergoing elective laparotomy under general anesthesia; age between 20 to 45 years and ASA grade I or II. Exclusion criteria: history of heart disease; history of lung disease;history of thyroid disease; history of neuromuscular disorders; liver or kidney dysfunction; alcohol abuse; drug abuser; Shivering during surgery and any complications during surgery that may require medical intervention.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Post Anesthetic shivering. Timepoint: 0, 10 and 20 minutes after entry to recovery room. Method of measurement: Quality Grading.;Body temperator. Timepoint: 0, 10 and 20 minutes after entry to recovery room. Method of measurement: Digital Termometer.	—

Secondary

Measure	Time frame
Saturation of Arterial O2. Timepoint: Before induction of Anaesthesia. Method of measurement: Palsoximetry.;Heart rate. Timepoint: before induction of Anaesthesia. Method of measurement: cardiac Monitoring.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hesamaldin Modir

Arak University of Medical Sciences

dr.hemodir@arakmu.ac.ir+98 86 1313 9793

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026