Anxiolytic effect of N2O

Clinical effects of inhalational nitrous oxide 50% on childbirth anxiety in cesarean section under spinal anesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012091510841N1

Enrollment

Registered

2012-10-24

Start date

2009-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Childbirth Anxiety under spinal anesthesia. Mental and behavioural disorders associated with the puerperium, not elsewhere classified

Interventions

Intervention 1: Intervention group: inhalation N2O%50 with oxygen by anesthesia mask. Patients received O2 & N2O %50 from 3 minutes before spinal anesthesia until birth time. Intervention 2: Control g

Treatment - Drugs

Placebo

Intervention group: inhalation N2O%50 with oxygen by anesthesia mask. Patients received O2 & N2O %50 from 3 minutes before spinal anesthesia until birth time.

Control group: inhalation oxygen %100 by anesthesia mask. Patients received O2 %100 from 3 minutes before spinal anesthesia until birth.

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: primigravid patients; 18-45 years old; educated; scheduled for cesarean section under spinal anesthesia. Exclusion criteria: Pre-eclampsia & Eclampsia; Vavular Heart Disease; Respiratory Disease; Previous Nausea &Vomiting; Ear Disease or Surgery; Increased ICP; Anemia; Shock; Patient refusal.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Anxiety Level. Timepoint: Befor spinal anesthesia and During spinal anesthesia, Skin Incision, Uterine Incision, Birth Time, Recovery Time. Method of measurement: Anxiety VAS.	—

Secondary

Measure	Time frame
Heart rate. Timepoint: every 5 minutes up to 15 minutes and every 15 minutes up to the end of the operation. Method of measurement: Puls oximetry.;Hallucination. Timepoint: During Surgery & Recovery Time. Method of measurement: Observation.;Nausea & Vomiting. Timepoint: During operation & Recovery Time. Method of measurement: Observation.;Systoilic & Diastolic Blood Pressure. Timepoint: every 5 minutes up to 15 minutes and every 15 minutes up to the end of the operation. Method of measurement: Non Invasive Blood Pressure Monitoring.	—

Measure

Time frame

Heart rate. Timepoint: every 5 minutes up to 15 minutes and every 15 minutes up to the end of the operation. Method of measurement: Puls oximetry.;Hallucination. Timepoint: During Surgery & Recovery Time. Method of measurement: Observation.;Nausea & Vomiting. Timepoint: During operation & Recovery Time. Method of measurement: Observation.;Systoilic & Diastolic Blood Pressure. Timepoint: every 5 minutes up to 15 minutes and every 15 minutes up to the end of the operation. Method of measurement: Non Invasive Blood Pressure Monitoring.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNahid Manouchehrian

Hamadan University Of Medical Sciences

manouchehrian@umsha.ac.ir+98 81 1827 7012

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026