Determination of effective drug in prevention of post spinal hypotension in C/S

Comparison of Intravenous bolus Phenylephrine and Ephedrine for prevention of postspinal Hypotension during Cesarean section.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120915010841N8

Enrollment

Registered

2018-06-23

Start date

2017-07-23

Completion date

Unknown

Last updated

2018-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post spinal anaesthesia hypotension. Other complications of spinal and epidural anaesthesia during labour and delivery

Interventions

Intervention 1: First intervention group : In this group immediately after the spinal anesthesia, 10 mg (1ml) of ephedrine which is a vaoconstrictor for prevetion of hypotension is injected intrav

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: ASA CLASS 1(Healthy Patients) 18-45 aged pregnant patients for C/S

Exclusion criteria

Exclusion criteria: Cardiac disease Renal disease History of hypertensive disease Diabetes Eclampsia &pre eclampsia Multiple pregnancy C/S for meconium or fetal distress Contraindications for spinal anesthesia

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Minutes of 0,2, 4, 6, 8, 10,15, 20, 25, 30, 40, 50 and 60 after spinal anesthesia. Method of measurement: Automatic non-invasive blood pressure device.;Diastolic blood pressure. Timepoint: Minutes of 0,2, 4, 6, 8, 10,15, 20, 25, 30, 40, 50 and 60 after spinal anesthesia. Method of measurement: Automatic non-invasive blood pressure device.;Mean arterial pressure. Timepoint: Minutes of 0,2, 4, 6, 8, 10,15, 20, 25, 30, 40, 50 and 60 after spinal anesthesia. Method of measurement: Automatic non-invasive blood pressure device.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Minutes of 0,2, 4, 6, 8, 10,15, 20, 25, 30, 40, 50 and 60 after spinal anesthesia. Method of measurement: Automatic non-invasive blood pressure device.;Diastolic blood pressure. Timepoint: Minutes of 0,2, 4, 6, 8, 10,15, 20, 25, 30, 40, 50 and 60 after spinal anesthesia. Method of measurement: Automatic non-invasive blood pressure device.;Mean arterial pressure. Timepoint: Minutes of 0,2, 4, 6, 8, 10,15, 20, 25, 30, 40, 50 and 60 after spinal anesthesia. Method of measurement: Automatic non-invasive blood pressure device.

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Secondary

Measure	Time frame
Heart rate. Timepoint: Minutes of 0,2, 4, 6, 8, 10,15, 20, 25, 30, 40, 50 and 60 after spinal anesthesia. Method of measurement: Pulse oximetry device.;Arterial oxygen saturation. Timepoint: Minutes of 0,2, 4, 6, 8, 10,15, 20, 25, 30, 40, 50 and 60 after spinal anesthesia. Method of measurement: Pulse oximetry device.;Nausea and vomiting. Timepoint: During surgery. Method of measurement: Observation.;Apgar Score of neonate. Timepoint: The first and fifth minutes after birth. Method of measurement: Examination and calculation on Apgar score.;The amount of ephedrine have been consumed. Timepoint: during surgery. Method of measurement: The amount of ephedrine have been consumed by mg.;The amount of atropine have been consumed. Timepoint: during surgery. Method of measurement: The amount of atropine have been consumed by mg.	—

Measure

Time frame

Heart rate. Timepoint: Minutes of 0,2, 4, 6, 8, 10,15, 20, 25, 30, 40, 50 and 60 after spinal anesthesia. Method of measurement: Pulse oximetry device.;Arterial oxygen saturation. Timepoint: Minutes of 0,2, 4, 6, 8, 10,15, 20, 25, 30, 40, 50 and 60 after spinal anesthesia. Method of measurement: Pulse oximetry device.;Nausea and vomiting. Timepoint: During surgery. Method of measurement: Observation.;Apgar Score of neonate. Timepoint: The first and fifth minutes after birth. Method of measurement: Examination and calculation on Apgar score.;The amount of ephedrine have been consumed. Timepoint: during surgery. Method of measurement: The amount of ephedrine have been consumed by mg.;The amount of atropine have been consumed. Timepoint: during surgery. Method of measurement: The amount of atropine have been consumed by mg.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNahid Manouchehrian

Hamedan University of Medical Sciences

manouchehrian@umsha.ac.ir+98 81 3827 7012

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026