The effect of Norepinephrine on the prevention of post spinal hypotension

Comparison of the effect of 5 and 10 µg bolus doses of intravenous norepinephrine on the prevention of hypotension after spinal anesthesia with 0.5% bupivacaine in cesarean section: a double-blind randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120915010841N24

Enrollment

126

Registered

2020-12-26

Start date

2020-07-22

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal anesthesia in cesarean section.

Interventions

Intervention 1: Intervention group1: Immediately after spinal anesthesia in group A, 5 micrograms of intravenous norepinephrine (with a volume of one ml) of 0.1% norepinephrine ampoule made by Normon

Eligibility

Sex/Gender

Female

Age

18 Years to 46 Years

Inclusion criteria

Inclusion criteria: Satisfaction to participate in the project Pregnant women aged 18 to 46 and term pregnancy Candidate for cesarean section under spinal anesthesia

Exclusion criteria

Exclusion criteria: Patients who have failed spinal anesthesia and undergo general anesthesia Lung disease, heart disease, fever, hypertension, diabetes and cardiac arrhythmia Emergency cesarean section due to meconium and fetal distress preeclampsia and eclampsia Multiple pregnancies Contraindications to spinal anesthesia (high ICP, hypovolemia, anemia, coagulation disorders, etc.) History of taking ergotamine Initial systolic pressure less than 90 mmHg

Design outcomes

Primary

Measure	Time frame
Blood pressure. Timepoint: Every two minutes to 10 minutes, then every 5 minutes to 15 minutes, and every 10 minutes until the end of the surgery. Method of measurement: Automatic non-invasive blood pressure device.	—

Secondary

Measure	Time frame
Heart Rate. Timepoint: Every two minutes to 10 minutes, then every 5 minutes to 15 minutes, and every 10 minutes until the end of the surgery. Method of measurement: pulse oximetry.;Nausea and Vomiting. Timepoint: During and after surgery. Method of measurement: Observation.;New born Apgar. Timepoint: 1&5 minutes after delivery. Method of measurement: Apgar Score.;The amount of ephedrine have been consumed. Timepoint: During surgery. Method of measurement: mg.;The amount of atropine have been consumed. Timepoint: During surgery. Method of measurement: mg.	—

Measure

Time frame

Heart Rate. Timepoint: Every two minutes to 10 minutes, then every 5 minutes to 15 minutes, and every 10 minutes until the end of the surgery. Method of measurement: pulse oximetry.;Nausea and Vomiting. Timepoint: During and after surgery. Method of measurement: Observation.;New born Apgar. Timepoint: 1&5 minutes after delivery. Method of measurement: Apgar Score.;The amount of ephedrine have been consumed. Timepoint: During surgery. Method of measurement: mg.;The amount of atropine have been consumed. Timepoint: During surgery. Method of measurement: mg.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNahid Manouchehrian

Hamedan University of Medical Sciences

manuchehriann@gmail.com+98 81 3827 7012

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026