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Comparison of two drugs in the prevention ofheadache after spinal anaestesia

Comparison of the effect of Dexamethasone and Methylergonovine injection in preventing headache after spinal anesthesia in Cesarean Section

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120915010841N11
Enrollment
100
Registered
2019-01-11
Start date
2018-07-01
Completion date
Unknown
Last updated
2019-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post dural puncture headache. Spinal and epidural anaesthesia-induced headache during labour and delivery

Interventions

Intervention 1: First Intervention group: After the birth of the baby and the clamp of the umbilical cord, a single dose of 8 mg dexamethasone phosphate (2ml), produced by the Caspian Company and pr

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Patients aged 18 to 45 years old candidates for cesarean section under spinal anesthesia Physical ASA Class 1 and 2

Exclusion criteria

Exclusion criteria: Patients with a history of migraine headache Sinusitis Heart disease Hypertension Eclampsia and pre-eclampsia Liver and kidney failure History of corticosteroid use Diabetes Raynoode Phenomen Spinal anesthesia contraindications (dissatisfaction, increased intracranial pressure, local infection, coagulopathy, anemia, hypovolemia, etc.) Patients who do not have the necessary co-operation in answering questions Those who are reluctant to continue to participate in the study Patients who have failed spinal anesthesia and undergo general anesthesia

Design outcomes

Primary

MeasureTime frame
Frequency of headache. Timepoint: During the surgery, the first 24 hours after surgery and one week after surgery. Method of measurement: Ask the patient.;Headache time. Timepoint: During the surgery, the first 24 hours after surgery and one week after surgery. Method of measurement: Ask the patient.;Headache severity. Timepoint: During the surgery, the first 24 hours after surgery and one week after surgery. Method of measurement: VAS of pain.;Duration of the headache. Timepoint: During the surgery, the first 24 hours after surgery and one week after surgery. Method of measurement: Ask the patient.

Secondary

MeasureTime frame
Nausea and vomiting. Timepoint: During the surgery. Method of measurement: Observation and ask the patient.;Heart Rate. Timepoint: Every two minutes for 10 minutes and then every 10 minutes to 60 minutes. Method of measurement: Pulse oximetry device.;Percentage of arterial oxygen saturation. Timepoint: Every two minutes for 10 minutes and then every 10 minutes to 60 minutes. Method of measurement: Pulse oximetry device.;Dizziness. Timepoint: During the surgery. Method of measurement: ask the patient.;Epigastric Pain. Timepoint: During the surgery. Method of measurement: ask the patient.;Tinnitus. Timepoint: During the surgery. Method of measurement: ask the patient.;Systolic Blood Pressure. Timepoint: Every two minutes for 10 minutes and then every 10 minutes to 60 minutes. Method of measurement: Non-invasive automatic barometric device.;Diastolic Blood Pressure. Timepoint: Every two minutes for 10 minutes and then every 10 minutes to 60 minutes. Method of measurement: Non-invasive automatic barometric device.;Mean Arterial Pressure. Timepoint: Every two minutes for 10 minutes and then every 10 minutes to 60 minutes. Method of measurement: Non-invasive automatic barometric device.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNahid Manouchehrian

Hamedan University of Medical Sciences

manuchehriann@gmail.com+98 81 3827 7012

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026