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Effect of low caloric diet with and without vitamin D supplementation in non alcoholic fatty liver

Effect of low caloric diet with and without vitamin D supplementation on trends of disease in non alcoholic fatty liver

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2012091310826N1
Enrollment
80
Registered
2013-02-02
Start date
2012-11-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

non alcoholic fatty liver. Nonalcoholic fatty liver disease (NAFLD)

Interventions

control group: using low caloric diet (kilo caloric/ body weight) - 500. 20% protein, 52% carbohydrate, 28% fat.also they use placebo of vitamin D weekly for 3 month.
Intervention 1: intervention group: using low caloric diet (kilo caloric/ body weight) - 500. 20% protein, 52% carbohydrate, 28% fat.also they use 50000 IU vitamin D weekly for 3 month. Intervention 2
Treatment - Drugs
Placebo
intervention group: using low caloric diet (kilo caloric/ body weight) - 500. 20% protein, 52% carbohydrate, 28% fat.also they use 50000 IU vitamin D weekly for 3 month.

Sponsors

Research services of shahid sadoughi university
Lead Sponsor

Eligibility

Sex/Gender
All
Age
25 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age between25 to65 years; Body mass index>=25; OH 25 Vitamin D<50 nmol/lit or 20 ng/ml; increase SGPT leve more than 40 mgr/dl; distinction of the grade of fatty liver by sconography and undrestanding by doctor. Exclusion criteria: liver disease like hepatitis; kidney disease; use low caloric diet or drugs for decrease weight in 6 month ago; lactation; gestation; use of steroid drugs; tamoxifen, prexilin, metotroxat, statin drugs; use of vitamin E & D 3 month ago; using alcoholic drinks; also patients that have weigh loss less than 5 percent of body or patients that without using 80 percent of vitamin D supplements will exclude from study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
SGPT. Timepoint: befor & after intervention. Method of measurement: mgr/dl, by blood sampling.;Liver and bile duct supersonic graphy. Timepoint: before & after intervention. Method of measurement: radiologic picture.;OH 25 vitamin D. Timepoint: before & after intervention. Method of measurement: ngr/dl, blood sample.;BMI. Timepoint: before & after intervention. Method of measurement: kgr/m2,.—

Secondary

MeasureTime frame
Waist circumfrence. Timepoint: before & after intervention. Method of measurement: cm,meter.;SGOT. Timepoint: before & after intervention. Method of measurement: mgr/dl,blood sample.;Billirobin. Timepoint: before & after intervention. Method of measurement: mgr/dl,blood sample.;Alkalin phosphat. Timepoint: before & after intervention. Method of measurement: IU, blood samlpe.;Calcium. Timepoint: before & after intervention. Method of measurement: mgr/dl,blood sample.;Phosphour. Timepoint: before & after intervention. Method of measurement: mgr/dl, blood sample.;Fasting Blood Sugar. Timepoint: before & after intervention. Method of measurement: mgr/dl.;Triglycerid. Timepoint: Before & after intervention. Method of measurement: mgr/dl,blood sample.;Total cholestrol. Timepoint: before & after intervention. Method of measurement: mgr/dl,blood sample.;HDL. Timepoint: before & after intervention. Method of measurement: mgr/dl,blood sample.;LDL cholestrol. Timepoint: before & after intervention. Method of measurement: mgr/dl,blood sample.;Weight. Timepoint: before & after intervention. Method of measurement: digital scale.;Height. Timepoint: before & after intervention. Method of measurement: stadiometer,m.—

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026