Effect of synbiotic supplementation in kidney stone disease

Investigating the impact of synbiotic supplementation on urinary biochemical and serum inflammatory markers in obese or overweight patients with a history of calcium oxalate kidney stone excretion

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120913010826N35

Enrollment

Registered

2024-11-21

Start date

2024-12-05

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nephrolithiasis. Chronic kidney disease (CKD)

Interventions

Intervention 1: Intervention group: Patients in this group will take two capsules of (Zist Takhmir Company) daily for 12 weeks. Each capsule contains a synbiotic combination of 12 beneficial and safe

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with a history of calcium oxalate kidney stone excretion Patients should be 18 to 65 years old. Willingness to cooperate and participate in the study. Be of either sex. Being in the range (body mass index) of more than 25 Normal serum creatinine concentration

Exclusion criteria

Exclusion criteria: Rheumatoid arthritis and pyelonephritis, lupus, kidney failure, and types of cancer (kidney, prostate, etc.). diabetes and thyroid disorders, blood pressure and parathyroid hormone disorders. infectious diseases such as chronic urinary tract infection and kidney infection. Taking blood sugar and blood pressure medications and insulin. Consumption of any prebiotic, probiotic or synbiotic supplement in the last three months. Continuous consumption of foods containing probiotics, including probiotic yogurt in the diet. Continuous use of antibiotics and multivitamin-mineral supplements, vitamin C, calcium, magnesium, vitamin D, and corticosteroids in the last three months. The experience of losing weight and consuming a variety of vegetarian and Mediterranean diets in the last three months.

Design outcomes

Primary

Measure	Time frame
24-hour urine oxalate concentration. Timepoint: Before the intervention and 12 weeks after the intervention. Method of measurement: Enzymatic method.;24-hour urine citrate concentration. Timepoint: Before the intervention and 12 weeks after. Method of measurement: Enzymatic method.;24-hour urine calcium concentration. Timepoint: Before the intervention and 12 weeks after. Method of measurement: Calorimetric.;24-hour urine uric acid concentration. Timepoint: Before the intervention and 12 weeks after. Method of measurement: Calorimetric.;24-hour urinary creatinine concentration. Timepoint: Before the intervention and 12 weeks after. Method of measurement: colorimetric.;Phosphorus concentration of 24-hour urine. Timepoint: Before the intervention and 12 weeks after. Method of measurement: Spectrophotometer.;24-hour urine magnesium concentration. Timepoint: Before the intervention and 12 weeks after. Method of measurement: Calorimetric.;Serum concentration high sensitivity c-reactive protein. Timepoint: Before the intervention and 12 weeks after. Method of measurement: The enzyme-linked immunosorbent assay (ELISA).;Malondialdehyde(MDA) serum concentration. Timepoint: Before the intervention and 12 weeks after. Method of measurement: Measurement of lipid peroxidation.;Serum concentration of total antioxidant capacity(TAC). Timepoint: Before the intervention and 12 weeks after. Method of measurement: Measurement of total antioxidant capacity.	—

Measure

Time frame

24-hour urine oxalate concentration. Timepoint: Before the intervention and 12 weeks after the intervention. Method of measurement: Enzymatic method.;24-hour urine citrate concentration. Timepoint: Before the intervention and 12 weeks after. Method of measurement: Enzymatic method.;24-hour urine calcium concentration. Timepoint: Before the intervention and 12 weeks after. Method of measurement: Calorimetric.;24-hour urine uric acid concentration. Timepoint: Before the intervention and 12 weeks after. Method of measurement: Calorimetric.;24-hour urinary creatinine concentration. Timepoint: Before the intervention and 12 weeks after. Method of measurement: colorimetric.;Phosphorus concentration of 24-hour urine. Timepoint: Before the intervention and 12 weeks after. Method of measurement: Spectrophotometer.;24-hour urine magnesium concentration. Timepoint: Before the intervention and 12 weeks after. Method of measurement: Calorimetric.;Serum concentration high sensitivity c-reactive protein. Timepoint: Before the intervention and 12 weeks after. Method of measurement: The enzyme-linked immunosorbent assay (ELISA).;Malondialdehyde(MDA) serum concentration. Timepoint: Before the intervention and 12 weeks after. Method of measurement: Measurement of lipid peroxidation.;Serum concentration of total antioxidant capacity(TAC). Timepoint: Before the intervention and 12 weeks after. Method of measurement: Measurement of total antioxidant capacity.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNiloofarsadat Maddahi

Yazd University of Medical Sciences

niloofar.maddahi110@gmail.com+98 35 3149 2232

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026