Resistance Training and Multiple Sclerosis

Effects of 12 weeks of Resistance Exercise Training on Serum Indices in Permeability of Blood Brain Barrier Controlling, oxidative stress, Functional capacity and cognitive performance in Women with Multiple Sclerosis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120912010824N3

Enrollment

Registered

2023-09-07

Start date

2021-05-07

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis. Other specified mental disorders due to known physiological condition

Interventions

Intervention 1: Intervention group: Resistance Training, Based on the recommendations in Resistance training (RT) for pwMS, the RT program included 12 weeks, 3 sessions/week, 60-80% 1RM for 60–90 min

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: history of at least two-year diagnosed RR-MS EDSS =4 no other chronic diseases (metabolic, cardiovascular, renal, …) no history of regular physical activity in the previous 6 months

Exclusion criteria

Exclusion criteria: No contracting COVID-19

Design outcomes

Primary

Measure	Time frame
Indices Related to Blood Brain Barrier Permeability (matrix metalloproteinases (MMPs) and specific tissue inhibitors of MMPs, s100B). Timepoint: pre and post of exercise protocol. Method of measurement: blood sampling.	—

Secondary

Measure	Time frame
Cognitive Performance. Timepoint: pre and post of exercise protocol. Method of measurement: The Brief International Cognitive Assessment for MS (BICAMS) was used to examine information processing speed and immediate verbal and visual recall. The BICAMS consists of the Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-II (CVLT-II) and the Brief Visuospatial Memory Test- Revised (BVMT-R).	—

Measure

Time frame

Cognitive Performance. Timepoint: pre and post of exercise protocol. Method of measurement: The Brief International Cognitive Assessment for MS (BICAMS) was used to examine information processing speed and immediate verbal and visual recall. The BICAMS consists of the Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-II (CVLT-II) and the Brief Visuospatial Memory Test- Revised (BVMT-R).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNasrin Niazi Nezhad

Kermanshah University of Medical Sciences

n.niazi64@gmail.com0834283276

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 8, 2026