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Effect of celecoxib on pain control after orthopedic surgery

Effects of Preoperative Celecoxib Administration on Pain Control After Tibial Fracture Surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120910010800N9
Enrollment
450
Registered
2022-12-07
Start date
2022-12-21
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Comminuted fracture of shaft of tibia. Comminuted fracture of shaft of tibia

Interventions

Intervention 1: Intervention group: Group A patients receive one celecoxib capsule and three placebo capsules one hour before surgery. Intervention 2: Intervention group: Intervention group: Group B p

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Consent to participate in the study Orthopedic surgery of tibial fracture with ORIF method

Exclusion criteria

Exclusion criteria: Uncontrolled underlying disease Chronic use of pain-relieving drugs Neuropathy History of allergic reactions to NSAIDs Mental illness Substance abuse Occurrence of medical problems after surgery The need for care in the intensive care unit after surgery

Design outcomes

Primary

MeasureTime frame
Postoperative pain. Timepoint: Recovery time, 6, 18, and 24 hours after surgery. Method of measurement: Using Visual Analogue Scale.

Secondary

MeasureTime frame
Postoperative nausea and vomiting. Timepoint: Recovery time, 6, 18, and 24 hours after surgery. Method of measurement: Patient's statement.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDariush Abtahi

Shahid Beheshti University of Medical Sciences

d.abtahi@sbmu.ac.ir+98 21 2263 2611

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026