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Effect of Labetalol on Reducing Postoperative Shivering after Cesarean Section under Spinal Anesthesia

Intravenous Labetalol for Prevention of Postoperative Shivering after Cesarean Section under Spinal Anesthesia: A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120910010800N15
Enrollment
120
Registered
2025-08-16
Start date
2025-09-01
Completion date
Unknown
Last updated
2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Shivering. Chills (without fever)

Interventions

Intervention 1: Intervention group: Intravenous bolus injection of 5 mg labetalol immediately after placental removal in cesarean section. Intervention 2: Control group: Intravenous injection of 0.9%

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Over 18 years old ASA physical status I or II Singleton pregnancy Gestational age = 37 weeks Elective cesarean section under spinal anesthesia

Exclusion criteria

Exclusion criteria: Lack of consent to participate in the study Known allergy or contraindication to labetalol History of hypertension under medical treatment Fever or infection at the time of surgery Use of medications affecting shivering Bradycardia, hypotension, or heart failure

Design outcomes

Primary

MeasureTime frame
Occurrence of shivering after spinal anesthesia (any shivering visible for = 15 seconds in the operating room and recovery room). Timepoint: During surgery and every 5 minutes for the first 60 minutes postoperatively in the PACU. Method of measurement: Patient observation by the anesthesiologist in charge of the patient.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDariush Abtahi

Shahid Beheshti University of Medical Sciences

d.abtahi@sbmu.ac.ir+98 21 2263 2611

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026