Tranexamic Acid in Spinal Surgery

Effect of Intravenous Tranexamic Acid Infusion (3 mg/kg/hr vs. 5 mg/kg/hr) Compared to Bolus-Only Administration on Blood Loss, Transfusion Requirements, and Hospital Stay in Adults Undergoing Elective Posterior Spinal Fusion Surgery: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120910010800N12

Enrollment

Registered

2025-04-08

Start date

2025-04-17

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraoperative hemorrhage. Intraoperative hemorrhage

Interventions

Intervention 1: Intervention group: Group A receive tranexamic acid at a dose of 3mg/kg/hr throughout the procedure. Intervention 2: Intervention group: Intervention group: Group B receive tranexamic

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: elective posterior spinal fusion surgery American Society of Anesthesiologists (ASA) Classification of Physical Status I, II no prior surgery in the relevant area BMI below 30 kg/m² Consent to participate in the study

Exclusion criteria

Exclusion criteria: History or presence of any type of coagulation disorder Recent use of coagulation-altering drugs

Design outcomes

Primary

Measure	Time frame
Intraoperative hemorrhage. Timepoint: After finishing surgery. Method of measurement: Counting surgical gases, determining the amount of blood collected in the suction bottle, estimating in the operating field.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDariush Abtahi

Shahid Beheshti University of Medical Sciences

d.abtahi@sbmu.ac.ir+98 21 2263 2611

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026