Effect of celecoxib on pain after orthopedic surgery

Comparing the preventive effect of celecoxib on pain after ankle fracture surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120910010800N11

Enrollment

Registered

2023-05-06

Start date

2023-05-10

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bimalleolar fracture of lower leg. Bimalleolar fracture of lower leg

Interventions

Intervention 1: Intervention group: Patients in the 400 group will receive two celecoxib 200 mg capsules the night before surgery and one placebo capsule one hour before surgery. Intervention 2: Inter

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Over than 18 years old Consent to the study

Exclusion criteria

Exclusion criteria: Substance abuse Uncontrolled underlying disease Underlying neuropathy

Design outcomes

Primary

Measure	Time frame
Postoperative pain. Timepoint: 6, 24 and 72 hours after the operation. Method of measurement: Using Visual Analogue Scale.	—

Secondary

Measure	Time frame
Postoperative nausea and vomiting. Timepoint: 6, 24, and 72 hours after surgery. Method of measurement: Patient's statement.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDariush Abtahi

Shahid Beheshti University of Medical Sciences

d.abtahi@sbmu.ac.ir+98 21 2263 2611

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026