Fractional CO2 laser and topical latanoprost in acral vitiligo

Comparison of the efficacy of topical latanoprost and fractional CO2 laser with placebo and fractional CO2 laser in treatment of vitiligo with acral involvement, phototherapy unit, Faghihi hospital, Shiraz, 2020

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120909010795N4

Enrollment

Registered

2020-12-08

Start date

2020-06-21

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitiligo. Vitiligo

Interventions

Intervention 1: Intervention group: 24 vitiligo patients with bilateral symmetrical lesions, on phototherapy, on one side took CO2 fractional laser (Microxel, MX7000, Korea) with energy level of 22 to

Eligibility

Sex/Gender

All

Age

14 Years to No maximum

Inclusion criteria

Inclusion criteria: Age more than 14 Acral vitiligo patche(s) resistant to phototherap Discontinue all systemic and topical treatments for 1 month At least 1 lesion in each side with size of 2*2 to 8*8 cm

Exclusion criteria

Exclusion criteria: Poor compliance Allergy to latanoprost Pregnant or breast-feeding women Age before 14 Uncontrolled systemic disorders that interfere with wound healing process Autoimmune disorders History of allergy to any drug Any psychological disorders Unilateral lesions Active infection at laser site History of keloids

Design outcomes

Primary

Measure	Time frame
Skin pigmentation. Timepoint: At the beginning of study and after 5 sessions of laser therapy, at the end of the study. Method of measurement: Qualitative assessment with VASI score and VAS.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Rahmanian

Shiraz University of Medical Sciences

rahmanian.f87@gmail.com+98 71 3231 9049

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026