Comparing the effectiveness of adding paracetamol and dexamethasone to lidocaine for intravenous block of upper extremity on severity of pain and period ?of painless during and after surgery.?? ?

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201209053104N2

Enrollment

Registered

2012-12-20

Start date

2012-04-03

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

IV Regional Anesthesia. Local anaesthetics

Interventions

Intervention 1: Group 1: Patients are received lidocaine (3 mg/kg), that diluted with normal saline to a total volume of 40 mL (Injection time: 90 seconds), for regional anesthesia. Intervention 2: Gr

Treatment - Drugs

Group 1: Patients are received lidocaine (3 mg/kg), that diluted with normal saline to a total volume of 40 mL (Injection time: 90 seconds), for regional anesthesia.

Group 2: Patients are received lidocaine (3 mg/kg) and dexamethason (8 mg), that diluted with normal saline to a total volume of 40 mL (Injection time: 90 seconds), for regional anesthesia.

Group 3:Patients are received lidocaine (3 mg/kg) and paracetamol (300 mg), that diluted with normal saline to a total volume of 40 mL (Injection time: 90 seconds), for regional anesthesia.

Group 4: patients are received lidocaine (3 mg/kg) and dexamethason (8 mg) and paracetamol (300 mg), that diluted with normal saline to a total volume of 40 mL (Injection time: 90 seconds), for region

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 20 to 60 years old; candidate for upper extremity surgery and ASA I or II. Exclusion criteria: Lidocaine allergy; infection; open fracture of limb; liver disease and addiction to opium and alcohol

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Surgical site pain. Timepoint: After the start of surgical process (at 5, 10, 15, 20, 30, 40 and 50 min) and after the end of surgery. Method of measurement: Visual Analogue Scale (VAS).;Onset and duration of sensory and motor block. Timepoint: From the start of anesthetics injection to the end of operation. Method of measurement: Evaluate the patients response to needle hitting on surgical site and request of the patients to hand flexion and extension.;Tourniquet site pain. Timepoint: After applying the tourniquet and during surgery (at 5, 10, 15, 20, 30, 40 and 50 min). Method of measurement: Visual Analogue Scale (VAS).	—

Measure

Time frame

Surgical site pain. Timepoint: After the start of surgical process (at 5, 10, 15, 20, 30, 40 and 50 min) and after the end of surgery. Method of measurement: Visual Analogue Scale (VAS).;Onset and duration of sensory and motor block. Timepoint: From the start of anesthetics injection to the end of operation. Method of measurement: Evaluate the patients response to needle hitting on surgical site and request of the patients to hand flexion and extension.;Tourniquet site pain. Timepoint: After applying the tourniquet and during surgery (at 5, 10, 15, 20, 30, 40 and 50 min). Method of measurement: Visual Analogue Scale (VAS).

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Secondary

Measure	Time frame
Mean Arterial Pressure (MAP). Timepoint: Before and after applying the tourniquet, during surgery (at 5, 10, 15, 20, 30, 40 and 50 min) and after opening the tourniquet. Method of measurement: By monitoring devices in the operating room (produced by Saadat Co).;Heart Rate. Timepoint: Before and after applying the tourniquet, during surgery (at 5, 10, 15, 20, 30, 40 and 50 min) and after opening the tourniquet. Method of measurement: By monitoring devices in the operating room (produced by Saadat Co).;Blood Oxygen Saturation. Timepoint: Before and after applying the tourniquet, during surgery (at 5, 10, 15, 20, 30, 40 and 50 min) and after opening the tourniquet. Method of measurement: By the pulse oximeter attached to the monitoring devices in the operating room (produced by Saadat Co).	—

Measure

Time frame

Mean Arterial Pressure (MAP). Timepoint: Before and after applying the tourniquet, during surgery (at 5, 10, 15, 20, 30, 40 and 50 min) and after opening the tourniquet. Method of measurement: By monitoring devices in the operating room (produced by Saadat Co).;Heart Rate. Timepoint: Before and after applying the tourniquet, during surgery (at 5, 10, 15, 20, 30, 40 and 50 min) and after opening the tourniquet. Method of measurement: By monitoring devices in the operating room (produced by Saadat Co).;Blood Oxygen Saturation. Timepoint: Before and after applying the tourniquet, during surgery (at 5, 10, 15, 20, 30, 40 and 50 min) and after opening the tourniquet. Method of measurement: By the pulse oximeter attached to the monitoring devices in the operating room (produced by Saadat Co).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Shabani

Neuroscience Research Center, Kerman University of Medical Science

shabanimoh@yahoo.com+98 34 1226 4196

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026