Effects of Platelet Rich Plasma in Treatment of patients with Long Bones Non-unions

Effects of Platelet Rich Plasma in Treatment of patients with Long Bones Non-unions: A Randomized Double-Blind Clinical Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201208262445N1

Enrollment

Registered

2012-09-23

Start date

2011-05-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonunion of fracture. Nonunion of fracture [pseudarthrosis]

Interventions

Intervention 1: Injection of 5 milliliters of plasma rich platelet (PRP) in the site of operation and forming a fascia and closing the wound. Intervention 2: Injection of normal saline in the site of

Treatment - Drugs

Placebo

Injection of 5 milliliters of plasma rich platelet (PRP) in the site of operation and forming a fascia and closing the wound

Injection of normal saline in the site of operation and forming a fascia and closing the wound

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age>18 years; long bone non-unions (Femur, Tibia, Fibula, Humerus, Ulna, Radius) with duration of more than 6 months Exclusion criteria: Age<18 years; infectious non-unions; vascular injuries; large skin defects of fracture site; musculoskeletal disorders; malignancies; pathological fractures (tumors, metabolic osteopenia); active autoimmune disorders; large bone defects; platelet count <100,000 per micro-liter; treatment with growth factors within the previous years; treatment with steroids and NSAIDs during the previous year

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical cure rate. Timepoint: Postoperaive days 45, 90, 135, 180, 225, 270. Method of measurement: Physical examination.;Radiological cure rate. Timepoint: Postoperaive days 45, 90, 135, 180, 225, 270. Method of measurement: Anteroposterio and lateral radiography views.	—

Secondary

Measure	Time frame
Incidence of infection. Timepoint: Postoperative days 45, 90, 135, 180, 225, 270. Method of measurement: Bacterial culture.;Muscular trophism. Timepoint: Postoperative days 45, 90, 135, 180, 225, 270. Method of measurement: Physcial examination.;Incedence of mal-union. Timepoint: Postoperative days 45, 90, 135, 180, 225, 270. Method of measurement: Anteroposterio and lateral radiography views.;Pain severity. Timepoint: Postoperative days 45, 90, 135, 180, 225, 270. Method of measurement: Visual Analogue Scale (VAS).	—

Measure

Time frame

Incidence of infection. Timepoint: Postoperative days 45, 90, 135, 180, 225, 270. Method of measurement: Bacterial culture.;Muscular trophism. Timepoint: Postoperative days 45, 90, 135, 180, 225, 270. Method of measurement: Physcial examination.;Incedence of mal-union. Timepoint: Postoperative days 45, 90, 135, 180, 225, 270. Method of measurement: Anteroposterio and lateral radiography views.;Pain severity. Timepoint: Postoperative days 45, 90, 135, 180, 225, 270. Method of measurement: Visual Analogue Scale (VAS).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFariborz Ghaffarpasand

Trauma Research Center, Shiraz University of Medical Sciences

ghafarf@sums.ac.ir+98 71 1233 4477

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026