Exacerbation of inflammatory responses following brain-death occurrence. Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
Conditions
Interventions
Intervention 1: Intervention Group: 100 mg/kg Ascorbic Acid administration and then starting to Continuous infusion of vit C, 100 mg/kg/p6h until the end of donor operation
Control Group: w
Treatment - Drugs
Intervention Group: 100 mg/kg Ascorbic Acid administration and then starting to Continuous infusion of vit C, 100 mg/kg/p6h until the end of donor operation
Control Group: without interven
Control group: routine practice
Sponsors
Vice chancellor for research, Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
10 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 10-60 y/o confirmed deadbrain case who has the UNOS standard criteria Exclusion criteria: The deadbrain patient who had a cardiac arrest
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene expression levels of IL6 and TNF-a genes. Timepoint: - 6 hours before the operation of deadbrain donor (in intervention group before starting to intervention) -Immediately after laparotomy -Immediately before clamping of Aorta. Method of measurement: Gene expression analysis using Real-Time PCR method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of AST, ALT and Bilirubin -T. Timepoint: 1, 3 and 10 days afetr liver transplantation. Method of measurement: Serum levels of AST, ALT and Bilirubin-T. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMasoumeh Kazemi
Shiraz University of Medical Sciences
Outcome results
None listed