Condition 1: major depression. Condition 2: Major depression. Recurrent depressive disorder, current episode severe without psychotic symptoms Severe depressive episode without psychotic symptoms
Conditions
Interventions
Intervention 1: Intervention: Ketamin (50 mg per ml, made by ROTEXMEDICA/Germany) 0.5_1mg/kg, administering stat and IV. Intervention 2: Control: Thiopental Na (50 mg per ml, made by Nani Pharmaceutic
Treatment - Drugs
Control: Thiopental Na (50 mg per ml, made by Nani Pharmaceuticals Pvt.Ltd) 3 mg/kg, administering stat and IV.
Intervention: Ketamin (50 mg per ml, made by ROTEXMEDICA/Germany) 0.5_1mg/kg, administering stat and IV.
Sponsors
Vice Chancellor for research of Kerman University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: all patients with MDD subjected to ECT who is validated by a psychiatric physician, age 18 – 50. Exclusion criteria: Ketamin contraindication, open eye injuries with high IOP, high ICP, intracranial tumors, tachycardia, high blood pressure, history of ischemic heart diseases, aneurism in main vessels, alcohol and drug consumption within last 3 months, history of Intracranial Hemorrhage(ICH),cardiovascular diseases, unstable medical illnesses, pregnancy, patients older or younger than mentioned age, weight more than 90Kg,allergy to Ketamin, hypo and hyperthyroidism, other mental disorders coexisted with MDD such as dementia and bipolar disorder, patients with pacemakers, patients without informed consent or their family are unreliable.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depression. Timepoint: before starting, after second, 4th, 6th session of ECT. Method of measurement: Hamilton questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure and heart rate. Timepoint: before induction, after ECT, 5, 10, 15 minutes later. Method of measurement: electronic monitoring device.;Duration of seizure. Timepoint: every session. Method of measurement: second.;Recovery time. Timepoint: after administration of anesthetic drugs until the patient's consciousness. Method of measurement: minute. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBehnaz Birjandi
Kerman University of Medical Sciences
Outcome results
None listed