Comparative efficacy of Tacrolimus ointment versus Calcipotriol ointment in vitiligo

Comparative efficacy of 0.1%Tacrolimus ointment versus 0.005% Calcipotriol ointment in perifollicular pigmentation in patients with hand and facial vitiligo

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201208144269N4

Enrollment

Registered

2012-10-10

Start date

2012-11-29

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitiligo. Vitiligo

Interventions

Intervention 1: Tacrolimus ointment (0.1%) manufactured by "Quality Care" which will be rubbed on the lesions once every night for one year. The weekly dosage used will be less than 100 grams. Interve

Treatment - Drugs

Tacrolimus ointment (0.1%) manufactured by "Quality Care" which will be rubbed on the lesions once every night for one year. The weekly dosage used will be less than 100 grams.

Calcipotriol ointment (0.005%) with the trade name of "Daivonex" manufactured by "Quality Care" which will be rubbed on the lesions once every night for one year. The weekly dose of the ointment will

Eligibility

Sex/Gender

All

Age

2 Years to 85 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1) Being older than 2 years old; 2) Vitiligo patients in which less than 20% of the face and hands are affected; 3) Willing to participate in the study Exclusion criteria: 1) History of herpes, dermatitis herpetiformis and any kind of active skin infections; 2) Patients with autoimmune hepatitis; 3) Patients with celiac disease; 4) Patients with immune system deficiency; 5) Pregnant or lactating women; 6) Patients with unknown systemic disorders; 7) Having simultaneous skin diseases other than vitiligo, malignancies or renal disorders

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Perifulicular pigmentation. Timepoint: At baseline and monthly for one year. Method of measurement: Photographs will be taken from the patients using a 12.1 mega pixel Cannon camera which has a lens zoom of 15*4.	—

Secondary

Measure	Time frame
Number of the lesions. Timepoint: At baseline and monthly for one year. Method of measurement: Counting visually.;Size of the lesions. Timepoint: At baseline and monthly for one year. Method of measurement: Evaluating the photographs taken from the lesions.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarideh Golfroushan

Tabriz University of Medical Sciences

golfroushanf@tbzmed.ac.ir+98 41 1540 6612

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026