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The effects of Phenylepherine and Ephedirne on maternal blood pressure and heart rate variation and umbilical cord arterial blood gases in spinal anesthesia

The effects of Phenylephrine & Ephedrine on maternal hemodynamic changes and umbilical cord arterial blood gases in spinal anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201208136148N2
Enrollment
100
Registered
2013-01-25
Start date
2012-05-30
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean Section. Complications of anaesthesia during labour and delivery

Interventions

Intervention 1: 100 microgram phenylepherine IV injection in one minute after spinal anesthesia to first group. Intervention 2: 10mg ephedrine IV prophylactic injection in one minute after spinal anes
Prevention
100 microgram phenylepherine IV injection in one minute after spinal anesthesia to first group
10mg ephedrine IV prophylactic injection in one minute after spinal anesthesia to second group

Sponsors

Vice-chancellor Of Research Babol University Of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:18 to 35 years pregnant women candided for cesarean secton with ASA class I,II Exclusion criteria: Hypertension BP>140/90; DM; Cardiovascular and cerbrovascular disease; Significant fetal abnormalities; contraindication of spinal anesthesia; mothers who are at the start of active phase of labor

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Blood pressure. Timepoint: Baseline BP before Spinal anesthesia and every 2 minutes control until the end of surgery. Method of measurement: Non invasive BP Cuff.;Heart rate. Timepoint: Before spinal anesthesia until the end of surgery every 2 minutes. Method of measurement: ECG.

Secondary

MeasureTime frame
Lactate of umbilical artery. Timepoint: Immediatly after birth. Method of measurement: ABG.;Infant Apgar. Timepoint: 1 and 5 minutes after birth. Method of measurement: Apgar Score.;Nausea & Vomiting. Timepoint: During spinal anesthesia. Method of measurement: Observation.;PH of umbilical artery. Timepoint: Immediatly after birth. Method of measurement: ABG.;Base excess. Timepoint: Immediatly after birth. Method of measurement: ABG.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hakimeh Alereza Amiri

Babol University Of Medical Sciences

halereza@yahoo.com , ans_dep@yahoo.com+98 11 1223 8296

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026