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Evaluation of efficacy of topical formulation of sildenafil 10% in diabetic foot ulcer healing

Evaluation of efficacy of topical formulation of sildenafil 10% in grade and depth of diabetic foot ulcer

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201208123449N10
Enrollment
100
Registered
2012-09-07
Start date
2013-01-18
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic food ulcers. Ulcer of lower limb, not elsewhere classified

Interventions

Intervention 1: Patients in case (intervention) group will be receive usual treatment of diabetic foot (including topical or systemic antibiotics) in addition to topical sildenafil ointment once daily
Treatment - Drugs
Placebo
Patients in case (intervention) group will be receive usual treatment of diabetic foot (including topical or systemic antibiotics) in addition to topical sildenafil ointment once daily for 3 weeks.

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: diabetic patients with Grade 1, stage A diabetic foot ulcers according to University of Texas Foot Wound Classification System, wh0 received standard care Exclusion criteria: patients with grade and stage more than 1, sensitivity reaction to topical formulation, unwillingness for entering in the study or discontinuation of follow up

Exclusion criteria

Exclusion criteria:

Design outcomes

Secondary

MeasureTime frame
Depth (stage) of diabetic ulcers. Timepoint: before intervention and then 7, 14 and 21 days after after intervention. Method of measurement: ulcers will be evaluated according to University of Texas Foot Wound Classification System.

Primary

MeasureTime frame
Grade of diabetic foot ulcer. Timepoint: before intervention and then 7, 14 and 21 days after after intervention. Method of measurement: ulcers will be evaluated according to University of Texas Foot Wound Classification System.

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026