Acute Ischemic Stroke. A stroke is caused by the interruption of the blood supply to the brain, usually because a blood vessel is blocked by a clot. This cuts off the supply of oxygen and nutrients, causing damage to the brain tissue.
Conditions
Interventions
Intervention 1: Case group receives G-CSF, 10 microgram per kilogram of body weight subcutaneously. However the first dose will be prescribed via intra venous line. Intervention 2: Control group will
Treatment - Drugs
Placebo
Case group receives G-CSF, 10 microgram per kilogram of body weight subcutaneously. However the first dose will be prescribed via intra venous line.
Control group will receive placebo (normal saline, 0.1 ml per kg of body weight). Participation in the study doesn’t produce any avoidance for receiving standard treatment of stroke.
Sponsors
Vice chancellor for research, Tehran University of Medical Sciences
Pooyesh darou Company
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion Critria: Age: 40-80; stroke was confirmed by DWI; less than 24 hours of beginning of stroke; NIHSS scale: 4-24; Stroke in MCA territory Exclusion critria: hypersensitivity to E coli proteins or G-CSF; History of cancer; History of severe renal, liver and hematological diseases; More than 2/3 of MCA territory; Pregnancy; The patient is candidate for rTPA; Acute ICH; Lacunar infarction
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical sign and symptoms. Timepoint: first week, 2nd week, 1st and 2nd and 3rd months. Method of measurement: NIHSS scale,Barthel Index Scale Score, modified rankin scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Lesion volume. Timepoint: one week. Method of measurement: Brain MRI(DWI and PWI). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Mohammad Hossein Harirchian
Tehran University of Medical Sciences
Outcome results
None listed