Head injury. Intracranial injury
Conditions
Interventions
Intervention 1: For patients in the intervention group administrated 1 mg / kg every 12 hours for up to 3 days of progesterone as IM injection. Intervention 2: For patients in control group, progest
Treatment - Drugs
For patients in the intervention group administrated 1 mg / kg every 12 hours for up to 3 days of progesterone as IM injection.
For patients in control group, progestrone not will be administratedAssesment of patients carry out according to GOS and FIM, one and three months after third day after admidet in hospital.
Sponsors
Islamic Azad University Najaf Abad
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: all male and female patients 18 years and more with admission GCS 8-4 during the first 8 hours on a voluntary and informed consent Exclusion criteria: injuries incompatible with life; bilateral dilated and no response to light pupils; spinal cord injury with neurological deficit; cardiopulmonary arrest; status epilepticus on arrival; initial systolic blood pressure less than 90; initial oxygen saturation less than 90%; pregnant women; any known previous or current cancer; known sensitivity to progesterone; known Coagulation disorders and lack of desire to continue research.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glasgow Outcome Score. Timepoint: One and three mounths after intervention. Method of measurement: GOS.;Functional Independence Measure. Timepoint: One and three mounts after intervention. Method of measurement: FIM. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMajid Kalbasi
Islamic Azad University Najaf Abad
Outcome results
None listed