Vomiting. Persons encountering health services for specific procedures and health care
Conditions
Interventions
Intervention 1: Patients in combination group recieve 2 capsule of gabapentin and 8 mg dexamethasone (2cc) intravenousely. Intervention 2: Medical intervention was done 1hr before surgery as following
Treatment - Drugs
Placebo
Patients in combination group recieve 2 capsule of gabapentin and 8 mg dexamethasone (2cc) intravenousely
Medical intervention was done 1hr before surgery as following in each group. Patients in the gabapentin group received 800mg Gabapentin (2 oral capsules) with 2cc saline normal intravenously (IV
Patients in dexamethasone group recieved 8 mg dexamethasone(2 cc) intravenousely and 2 placebo capsule identical to gabapentin.
In control (placebo) group patients recieve 2 cc normal saline intravenousely and 2 placebo capsules orally
Sponsors
Deputy of research of Tehran university of medical sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients scheduled for Tympanomastoidectomy under general anesthesia; ASA class I,II patients; patients aged between 20-60 years. Exclusive criteria : prior history of PONV; smokers; hypersensitivity to any of study drugs; serious organ disease/dysfunction; persistent preoperative pain; prior use of analgesic; alcohol/substance abuse; a major psychiatric disorder; a bleeding disorder; peptic ulcer disease; asthma/COPD and a seizure disorderl; patients who had received anti emetics within 24 hr before scheduled surgery or received sedatives (7, 8) and duration of operation more than 3 hours.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nausea and vomiting. Timepoint: Frequency of Nausea & vomiting during 24 hours post-operation. Method of measurement: According to self report of patients. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed