The effect of a restrictive pulmonary disease and relevant medical interventions on Brain Hemodynamics. Hyaline membrane disease
Conditions
Interventions
Intervention 1: Control group: Non-invasive ventilation based on one level of pressure during intervention. Intervention 2: Intervention group: the neonate receiving non-invasive respiratory support w
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
7 Months to 8 Months
Inclusion criteria
Inclusion criteria: Premature infants with the gestational age of 28 to 32 weeks still receiving nCPAP support 72 hours after birth whose first surfactant administration was during the first 2 hours after birth Neonates receiving nCPAP support in order to maintain oxygen saturation (89%-95 at right hand) 72 hours after birth while CDP is at 4-6 cm H20 and FiO2 is at 30%-40%.
Exclusion criteria
Exclusion criteria: Perinatal Asphyxia (Apgar at fifth minute=0-3, Umbilical cord pH<7, Umbilical cord Bicarbonate < 12 mEq/L), Congenital Malformation Neonates whose first surfactant administration is 2 hours after birth Neonates with no surfactant administration Neonates showing evidence of PDA through Echocardiography Neonates under administration of Inotrope drugs Neonates showing evidence of GM-IVH in grades III-IV in cranial sonography Neonates with air leakage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number and duration of sleep-wake cycle. Timepoint: before intervention during a 6-hour period and during a 6-hour interval after intervention. Method of measurement: Using amplitude integrated EEG (Electroencephalography). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza Sadeghnia
Esfahan University of Medical Sciences
Outcome results
None listed