Shortage of surfactant causes RDS in neonates.. Respiratory distress syndrome of newborn
Conditions
Interventions
Intervention 1: Control group: Neonates assigned to the bubble-CPAP group will receive nCPAP via appropriately sized nasal prongs (Fisher & Paykel Healthcare, Auckland, New Zealand). Continuous disten
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Days to 1 Days
Inclusion criteria
Inclusion criteria: Newborns with a range of 26 to 30 weeks of gestation Clinical symptoms associated with RDS (tachypnea, intercostal retraction, nasal flaring, grunting, need for FiO2 higher than 21%
Exclusion criteria
Exclusion criteria: Major congenital malformations (congenital diaphragmatic hernia, tracheoesophageal fistula, Pierre Robin sequence, choanal atresia) Possibility of chromosomal abnormalities Weak respiratory effort, which may be accompanied by apnea or require invasive ventilation during NICU admission Manifestations of shock, pulmonary hemorrhage, or the possibility of persistent pulmonary hypertension Severe respiratory acidosis (pH60 mm Hg) Severe metabolic acidosis (pH10 mEq/L)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Investigating the need for invasive mechanical ventilation (nCPAP failure) within 72 hours of birth in the management of Respiratory Distress Syndrome in neonates with the gestational age of 26-30 weeks: Comparing Seattle PAP vs. Bubble-CPAP. Timepoint: 72 hours. Method of measurement: Investigating arterial blood gases. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza Sadeghnia
Esfahan University of Medical Sciences
Outcome results
None listed