Assessment the Effect of Myrtus Communis L. (Myrtle) fruit in treatment of gastroesophageal reflux disease

Double blind randomized clinical trial in treatment of gastroesophageal reflux disease with Myrtus Communis L. (Myrtle) fruit vs. omeprazole

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012072710410N1

Enrollment

Registered

2013-02-10

Start date

2012-07-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastroesophageal reflux. gastroesophageal reflux without esophagitis

Interventions

Intervention 1: Control group: omeprazole capsule (once a day before breakfast). Intervention 2: Case group1: Myrtus Communis L. (Myrtle) fruit capsule (twice a day, before breakfast and dinner). Inte

Treatment - Drugs

Control group: omeprazole capsule (once a day before breakfast)

Case group1: Myrtus Communis L. (Myrtle) fruit capsule (twice a day, before breakfast and dinner).

Case group2: Myrtus Communis L. (Myrtle) fruit capsule (twice a day, before breakfast and dinner) + omeprazole capsule (once a day before breakfast).

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: having the classic symptoms of reflux; patients with 18-50 years old. Exclusion criteria: suffering from another disease; ongoing alcohol users; weakly cooperative patients; pregnant women; breast feeding women; women in fertility ages without any contraceptive method; diabetic patients;, erosive GERD; smoker patients.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Reflux symptoms. Timepoint: before intenvention and four weeks after starting the intervention. Method of measurement: visual analogue scale , frequency scale for symptoms of gastroesophageal reflux disease.	—

Secondary

Measure	Time frame
Headache after reflux. Timepoint: before intervention and four weeks after intervention. Method of measurement: according Statements.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Rahimeh Akrami

Shiraz University of Medical Sciences

akrami@sums.ac.ir+98 71 1230 5410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026