Gastro-oesophageal reflux disease. Gastro-oesophageal reflux disease
Conditions
Interventions
Intervention 1: Omeprazole (20 mg twice daily) for four months followed by one month washout and four months of placebo. Intervention 2: Reverse treatment: Placebo twice daily for four months, then on
Treatment - Drugs
Placebo
Omeprazole (20 mg twice daily) for four months followed by one month washout and four months of placebo
Reverse treatment: Placebo twice daily for four months, then one month washout period, then omeprazole 20 mg twice daily for four months
Sponsors
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Male; Chemical warfare victim; Having a history of exposure to mustard gas; Having symptoms of chronic cough (more than 3 weeks); Having symptoms of GERD; Willing to participate Exclusion criteria: Current smokers; Having previous history of smoking; Being under recent anti-reflux therapy; Contraindication for using omeprazole
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GERD Symptoms. Timepoint: Before and After the Trial. Method of measurement: Questionnaire.;Cough Symptoms. Timepoint: Every one month. Method of measurement: Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life. Timepoint: Before and After the Trial. Method of measurement: Questionnaire.;Pulmonary Function. Timepoint: Before and After the Trial. Method of measurement: Spirometry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Mohammad Talaei
Isfahan University of Medical Sciences and Poursina Hakim Research Institute
Outcome results
None listed