Effects of Vitamin C in Prevention of Atrial Fibrillation after coronary artery bypass graft (CABG)

Effects of Vitamin C in Prevention of Atrial Fibrillation after coronary artery bypass graft (A Placebo-Controlled Randomized Clinical Trial)

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201207243799N3

Enrollment

170

Registered

2012-11-05

Start date

2012-07-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease. Atherosclerotic heart disease

Interventions

Intervention 1: Patients in the control group receive placebo (Normal Saline intravenously). Intervention 2: In the intervention group, a total of 7.0 grams intravenous Vitamin C is administered as: 2

Prevention

Patients in the control group receive placebo (Normal Saline intravenously).

In the intervention group, a total of 7.0 grams intravenous Vitamin C is administered as: 2.0 g (4 ampules), 12 hours before surgery and 500 mg (1 ampule), twice a day for five days after surgery. In

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Patients with coronary artery disease (on angiography) who are candidate for coronary artery bypass. Exclusion Criteria: 1- Patients above 80 years old. 2- Patients who have Atrial Fibrillation before surgery. 3- Patients with heart valve disease or arrhythmia or having every degree of heart block conduction. 4- Patients who use a pacemaker. 5- Patients who have chronic lung, liver or kidney disease. 6- Patients who have other heart surgeries simultaneously with bypass surgery. 7- History of using anti-arrhythmic drugs. 8- Having sick sinus syndrome. 9- Having symptoms of urinary stone or history of kidney stones. 10- History of using Vitamin C in the recent quarter.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Duration of hospital stay. Timepoint: At discharge time. Method of measurement: Refer to the Patient file.;AF rhythm. Timepoint: Continuous monitoring for the first 72 hours after CABG surgery and then daily ECG. Method of measurement: ECG recording device.;Length of stay in ICU. Timepoint: At the time of transferring to the ward. Method of measurement: Refer to the data sheet in ICU.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNasim Shayan

Cardiac Surgery and Transplantation Research Center of Dr. Shariati Hospital

ctrc@tums.ac.ir; nsm_shayan@yahoo.com+98 21 8863 3037

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026