Mucositis. Acute radio dermatitis
Conditions
Interventions
Intervention 1: Intervention: Aloe vera mouth rinse, chemical composition: Aloe vera gel 100%, concentration of 0.0009% Blue color Brilliant Blue, concentration of 0.0006% yellow color Tarterazine, ma
Prevention
Intervention: Aloe vera mouth rinse, chemical composition: Aloe vera gel 100%, concentration of 0.0009% Blue color Brilliant Blue, concentration of 0.0006% yellow color Tarterazine, manufacturer: Bary
Control: Benzydamine hydrochloride Mouth rinse, chemical composition: Benzydamine hydrochloride 0/15 %, manufacturer: pharmaceutical company Behvazan, brand: Behvazan 0/15% - During 6 weeks of Radioth
Sponsors
Baryj Essence Pharmaceutical Company
Vice chancellor for research, school of Dentistry Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Minimum age: 18 years, diagnosed cancer in the head and neck region, the minimum therapeutic dose of 50 Gy, oral cavity is placed in the radiation field, the patient's ability to cooperate and use medications as directed. Exclusion criteria: Patients with a history of cancer treatment during the last year, patients with a history of food allergy, oral lesions including active infection, mouth ulcers before starting the radiation therapy, lack of patient willingness and cooperation to participate in the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mucositis grade. Timepoint: From Starting of radiation therapy, weekly during 6 weeks of treatment and 1 week after treatment. Method of measurement: questionnaire based on the Mucositis grade rating items from the World Health Organization (WHO). | — |
Secondary
| Measure | Time frame |
|---|---|
| Mouth soreness. Timepoint: From starting of radiation therapy, weekly during 6 weeks of treatment and 1 week after treatment. Method of measurement: Questionnaire (Asking from patient).;Ulcer. Timepoint: From starting of radiation therapy, weekly during 6 weeks of treatment and 1 week after treatment. Method of measurement: Questionnaire (Observation).;Disability to swallowing solid food. Timepoint: From starting of radiation therapy, weekly during 6 weeks of treatment and 1 week after treatment. Method of measurement: Questionnaire (Asking from patient).;Disability to alimentation. Timepoint: From starting of radiation therapy, weekly during 6 weeks of treatment and 1 week after treatment. Method of measurement: Questionnaire (Asking from patient).;Erythema. Timepoint: From starting of radiation therapy, weekly during 6 weeks of treatment and 1 week after treatment. Method of measurement: Questionnaire (Asking from patient and observation). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDoctor Arash Mansourian
School of Dentistry Tehran University of Medical Sciences, oral medicine Department
Outcome results
None listed