Multiple sclerosis. Multiple sclerosis
Conditions
Interventions
Intervention 1: Intra venous Methyl-prednisolone pulse 1mg/day in 3-5 days. Intervention 2: Plasma Exchange as Intervention
Corticoestroid received patients as Controls.
Treatment - Drugs
Treatment - Devices
Intra venous Methyl-prednisolone pulse 1mg/day in 3-5 days
Plasma Exchange as Intervention
Corticoestroid received patients as Controls
Sponsors
Isfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1- Relapsing-Remiting Multiple Sclerosis (RR-MS) patients with severe relapses, 2- Indicated for corticoestroid therapy, Or indicated for Plasma Exchange therapy 3- Satisfaction of patients to participate in the study 4- Not reception of any Immunomodulatory treatment atleast in last 2 months 5- Having more than 15 and less than 50 years age Exclusion criteria: 1-Those patients who dont complete the course of therapy with any reason 2- Those patients who have not any of the above mentioned including criteria 3- Patients who have other types of MS disease apart from RR-MS
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Regulatory T lymphocytes frequency. Timepoint: Befor the first and at the end of last session of treatment. Method of measurement: Flowcytometry.;Th17 lymphocytes frequency. Timepoint: before the first and at the end of last session of treatment. Method of measurement: Flowcytometry. | — |
Secondary
| Measure | Time frame |
|---|---|
| EDSS. Timepoint: 1-2 weeks after last session of Plasma Exchange. Method of measurement: EDSS table ( performs by a Neurologist ). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzam Jamshidian
Isfahan University of medical Sciences
Outcome results
None listed