Investigation of Berberis aristata root effect versus metformin tablet on blood sugar in diabetic patients .

Investigation of the safety profile , metabolic and pharmacodynamic effect of extract of Berberis aristata versus metformin tablet on blood glucose in patients with type 2 diabetic mellitus.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201207191774N5

Enrollment

Registered

2014-08-15

Start date

2013-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabet mellitus. non insulin dependent diabetes mellitus

Interventions

Intervention 1: first group:intervention group( Berberis aristata capsule and metformin placebo tablet) use Berberis aristata capsule (methanol extract of Berberis aristata root ) as 500mg daily for

Treatment - Drugs

first group:intervention group( Berberis aristata capsule and metformin placebo tablet) use Berberis aristata capsule (methanol extract of Berberis aristata root ) as 500mg daily for three months and

second group:control group (metformin tablet and Berberis aristata placebo capsule) use metformin tablet as 500mg two times a day after breakfast and dinner for three month and are in control of exerc

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Newly diagnosed type 2 diabetes based on ADA 2011 [14], 18-75 years old, Both sexes, Capable to swallow, No other tablet except metformine, No insulin therapy, No chronic inflammatory disease [17] Exclusion criteria: Fasting blood sugar more than 250 mg/dl, HbA1C more than 10%, Patients with chronic complications of diabetes, Pregnancy, Lactation, Known liver, renal or neurologic diseases (based on clinical examination, interview with patient or previously endorsed documents with the patients).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Plasma glucose. Timepoint: during of study. Method of measurement: blood sample.;Hba1c. Timepoint: after 3 month. Method of measurement: blood sample.;Fructose amin. Timepoint: after 2 weeks. Method of measurement: blood sample.	—

Secondary

Measure	Time frame
Laboratory Tests. Timepoint: after 0-15-45-90 days. Method of measurement: blood and urine sample.;Weight and blood prussre and others. Timepoint: after 0-15-45-90 days. Method of measurement: Barometer system and standard weight.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mojgan Sanjari

Kerman Afzalipour Hospital

msanjari@kmu.ac.ir+98 341322225070

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026