Proteinuria. Persistent proteinuria, unspecified
Conditions
Interventions
Intervention 1: Intervention group: A diet will be designed and recommended to intervention group that its phosphorus content will be limited to 10 to 12 mg/kg/day. The intervention duration will be 8
Sponsors
Kashan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients with proteinuria in whom the ratio of protein to creatinine in a sample of urine is greater than 0.3 mg/mg The glomerular filtration rate (eGFR) should be greater than 15 mL/min/1.73 m2 The systolic blood pressure should be less than 150 mmHg The serum level of phosphorus should be more than 3 mg/dL Dietary intake of phosphorus should be more than 17-20 mg/kg/day Patients in whom at least 3 months have passed from the onset of anti-proteinuric medications use Patients with proteinuria and diabetes in whom at least 3 months have passed from the onset of taking the glucose lowering drugs or insulin The amount of medications consumed should be constant within 3 months before the start of the study and their type and dosage do not change during the intervention
Exclusion criteria
Exclusion criteria: Pregnancy Lactation Patients with urinary tract infections Patients with pyelonephritis Patients with kidney stones consumption of various kind of phosphate binders Taking calcium and vitamin D supplements within 3 months before the start of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A change in urine protein to creatinine ratio. Timepoint: At baseline and 8 weeks after the start of the phosphorus restricted diet or control diet. Method of measurement: Laboratory clinical kit and analyzer instrument. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum level of phosphorus. Timepoint: At baseline and 8 weeks after the start of the phosphorus restricted diet or control diet. Method of measurement: Laboratory clinical kit and analyzer instrument.;Urine levels of phosphorus. Timepoint: At baseline and 8 weeks after the start of the phosphorus restricted diet or control diet. Method of measurement: Laboratory clinical kit.;Serum level of fibroblast growth factor 23 (FGF23). Timepoint: At baseline and 8 weeks after the start of the phosphorus restricted diet or control diet. Method of measurement: Laboratory clinical kit and analyzer instrument.;A change in glomerular filtration rate (eGFR). Timepoint: At baseline and 8 weeks after the start of the phosphorus restricted diet or control diet. Method of measurement: CKD-EPI formula.;Serum levels of creatinine. Timepoint: At baseline and 8 weeks after the start of the phosphorus restricted diet or control diet. Method of measurement: Laboratory clinical kit and analyzer instrument.;Serum levels of uric acid. Timepoint: At baseline and 8 weeks after the start of the phosphorus restricted diet or control diet. Method of measurement: Laboratory clinical kit and analyzer instrument. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNegar Mozaffari Rad
Kashan University of Medical Sciences
Outcome results
None listed