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The effect of sertraline with or without propranolol on the panic attack

The effect of sertraline with or without propranolol on the panic attack in women: a double blind randomized controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120718010324N70
Enrollment
60
Registered
2022-08-31
Start date
2022-08-10
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Panic disorder. Panic disorder [episodic paroxysmal anxiety] without agoraphobia

Interventions

Intervention 1: Intervention group: The participants (30 women) will receive propranolol (Propranolol hydrochloride tablet oral 10 mg) with the trade name (Pranol®) at a dose of 10-20 mg plus sertrali

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Women Women with researcher-diagnosed panic disorder (psychiatrist) based on diagnosis criteria (DSM-IV) Sufficient literacy to complete the questionnaire or accompany a literate person in the family

Exclusion criteria

Exclusion criteria: Abuse of tobacco and alcohol The occurrence of a stressful event (such as divorce, death of a first-degree family member, diagnosis of a terminal or incurable disease for a family member within the last three months, and job loss) Systemic disorders (such as cardiovascular, diabetes, asthma, digestive, liver, blood, endocrine) Taking antidepressants (such as antihistamines, barbiturates, narcotics, diazepam, amphetamines, and cocaine)

Design outcomes

Primary

MeasureTime frame
Panic attack. Timepoint: At the beginning of the study and 4 weeks after the start of consumption. Method of measurement: Panic Disorder Severity Scale – Self Report Form (PDSS-SR).

Secondary

MeasureTime frame
Depression score. Timepoint: At the beginning of the study and 4 weeks after the start of consumption. Method of measurement: Beck Depression Inventory short form.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSepideh Mashayekh Amiri

Tabriz University of Medical Sciences

Sepidehmashayekh@yahoo.com+98 41 3479 6770

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026