Atrophic vaginitis. Postmenopausal atrophic vaginitis
Conditions
Interventions
Intervention 1: The intervention group will receive Ginseng capsule 500 mg twice a day for four weeks. Intervention 2: The control group will receive placebo capsule with the same appearance and order
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: Married women with monogamous husband Having age between 45 to 60 years Passing minimum 12 months and maximum 10 years from the Last menstrual period Having sexual intercourse at least two times per month Natural menopause, not after surgery (hysterectomy)
Exclusion criteria
Exclusion criteria: Coronary artery disease or other heart problems such as significant arrhythmia Uncontrolled diabetes mellitus, Uncontrolled hypertension Blood pressure lower than 90/50 mmHg, A history of radical hysterectomy Anatomical deformity of external genitalia A history of cerebrovascular disease or central nervous system disease A history of spinal cord injury or related surgery Liver dysfunction Kidney dysfunction Taking of medicines such as Amlodipine, Valerian, and Lorazepam (which are known to have interactions with ginseng) A history of chemotherapy or pelvic radiation Having mental disorders such as schizophrenia, mania and ... Present use of phytoestrogens and other complementary or herbal medicines Existence of post coital bleeding or spotting
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vaginal maturation index. Timepoint: Before and 4 weeks after intervention with drug/placebo. Method of measurement: To determine the vaginal maturation index, the liquid base pap-smear will prepare before and after intervention, and the related index will calculate by the pathologist.;Vaginal pH. Timepoint: Before and 4 weeks after intervention with drug/placebo. Method of measurement: The vaginal pH will be measured with Merck's pH meter strips with a precision of 0.5.;Atrophic vaginitis symptoms. Timepoint: Before and 4 weeks after intervention with drug/placebo. Method of measurement: To determine the atrophic vaginitis symptoms, a 5-items questionnaire including vaginal dryness, itching, burning, abnormal discharge and dyspareunia will be used. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pelvic floor muscles strength. Timepoint: Before and 4 weeks after intervention with drug/placebo. Method of measurement: International Consultation on Incontinence Questionnaire Urinary Incontinence Short Form (ICIQ-short form) including 4-items. will be used for assessing the pelvic floor muscles strength. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Ghorbani
Tabriz University of Medical Sciences
Outcome results
None listed