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Does extension of remote ischemic preconditioning have cardioprotective effect on patients underwent CABG surgeries?

Does extension of remote ischemic preconditioning have cardioprotective effect on patients underwent CABG surgeries?

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2012071710311N1
Enrollment
120
Registered
2012-08-18
Start date
2012-08-05
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coranary artery bypass graft. Unspecified complication of cardiac and vascular prosthetic device, implant and graft

Interventions

Intervention 1: A blood pressure cuff on the upper arm and the second cuff on the thigh will be applied. In Group I, upper arm tourniquet cuff will be inflated rapidly to 100 mmHg over the initial sy
Prevention
A blood pressure cuff on the upper arm and the second cuff on the thigh will be applied. In Group I, upper arm tourniquet cuff will be inflated rapidly to 100 mmHg over the initial systolic blood pre
In group II when the upper limb cuff is deflated the lower limb cuff will be inflated and vice versa.
In the third group, or control group, none of the cuffs will be inflated.

Sponsors

Shiraz university of medical sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with coronary artery disease requiring bypass surgery (preoperative troponin I level 2); Renal failure (Cr> 1.7).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Troponin I. Timepoint: Before induction of anesthesia , 6 hours after operation , the first day after surgery , the second day after surgery. Method of measurement: Chemiluminescence Test for Blood.

Secondary

MeasureTime frame
BUN. Timepoint: Before induction of anesthesia. 6 hours after operation. First, second and third post operative day. Method of measurement: Blood serum,chemical u.v serum analysis.;Arrhythmia after declamping aorta, and during discontinuation of cardiopulmonary bypass. Timepoint: In operating room during discontinuation of cardiopulmonary bypass. Method of measurement: Monitoring and observation.;Type and dose  of inotrop required. Timepoint: During discontinuation of cardiopulmonary bypass. Method of measurement: Type and dose  of drug.;Duration of inotrop usage. Timepoint: From time to 3 days after discontinuation of cardiopulmonary bypass surgery. Method of measurement: Monitor and measure time.;Createnine. Timepoint: Before induction of anesthesia. 6 hours after operation. First, second and third post operative day. Method of measurement: blood ,jaffe analysis.;Ckmb. Timepoint: Before induction of anesthesia. 6 hours after operation. First, second and third post operative day. Method of measurement: blood chemical IFCC-DGKC Photometry.;Hb/Hct. Timepoint: Before induction of anesthesia. after disconection of cardiopulmonary pump. First, second and third post operative day. Method of measurement: analyze hemolyzed blood using spectrophotometric detection.;K. Timepoint: Before induction of anesthesia. 6 hours after operation. First, second and third post operative day. Method of measurement: Ion- selective electrodes analysis.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli karmi

Shiraz university of medical sciences

Alk1380@gmail.com+98 71 1647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026