Ectopic pregnancy. Ectopic pregnancy, unspecified
Conditions
Interventions
Intervention 1: Intervention group: In the multi-dose regimen, 1 mg / kg methotrexate will be injected on days of 1, 3, 5, and 7. It should be noted that in these days, ßHCG titer will be measured bef
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Satisfaction with participating in the study Confirmation of ectopic pregnancy by ultrasound and ßHCG Stable hemodynamic status the gestational sac with the largest diameter of, 4 cm; Existence of low free fluid in the abdominal and pelvic cavity based on ultrasound.
Exclusion criteria
Exclusion criteria: The presence of active hepatitis The presence of kidney disease Use of immunosuppressive drugs History of severe allergy to methotrexate Leukopenia in patient CBC tests Hematopoiesis disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum ßHCG level. Timepoint: On days 1, 3, 5 and 7 after injection of methotrexate. Method of measurement: blood test.;Outcome of treatment. Timepoint: 6 weeks after starting treatment. Method of measurement: The outcome of treatment is assessed as follows: The success of single-dose treatment means a 5% reduction in serum hCG levels after one week of treatment and a serum level of less than 5 mIU / mL after 6 weeks of treatment. In the multi-dose regimen, a 15% decrease in hCG serum levels after 48 hours of treatment or after 4 therapeutic doses, or hCG serum levels less than 5 mIU / mL after 6 weeks of treatment will be regarded as success of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Methotrexate complications such as Hair loss, gastroenteritis, Neutropenia, Fever, and Increase in liver enzyme. Timepoint: during the treatment up to six weeks after. Method of measurement: Clinical observation and doctor's diagnosis. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBehnaz Khani
Esfahan University of Medical Sciences
Outcome results
None listed