Histological study of Ca(OH)2 effect and different concentrations of SIMVASTATIN on pulp-dentin complex response after Direct Pulp Capping

Histological study of Ca(OH)2 effect and different concentrations of SIMVASTATIN on pulp-dentin complex response after Direct Pulp Capping . on primary molars of 7-9 years old children who had serial extraction treatment plan, hard tissue formation was evaluated.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2012071410276N1

Enrollment

Registered

2012-09-16

Start date

2011-07-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries. Dental caries

Interventions

Intervention 1: Control group: Direct pulp capping by calcium hydroxide for 6-9 months. Direct pulp capping (DPC) involves the application of a medicament, dressing or dental material on the exposed

Rehabilitation

Control group: Direct pulp capping by calcium hydroxide for 6-9 months. Direct pulp capping (DPC) involves the application of a medicament, dressing or dental material on the exposed pulp in an atte

Intervention group (2): Direct pulp capping by 1 µM/L simvastatin for 6-9 months. Direct pulp capping (DPC) involves the application of a medicament, dressing or dental material on the exposed pulp

Intervention group (3): Direct pulp capping by 5 µM/L simvastatin for 6-9 months . Direct pulp capping (DPC) involves the application of a medicament, dressing or dental material on the exposed pulp

Intervention group (4): Direct pulp capping by 10 µM/L simvastatin for 6-9 months. Direct pulp capping (DPC) involves the application of a medicament, dressing or dental material on the exposed pulp

Eligibility

Sex/Gender

All

Age

7 Years to 9 Years

Inclusion criteria

Inclusion criteria: Cases were selected considering the following inclusion criteria: 1.primary first and second molars. 2.deep caries but no indication for pulpotomy or pulp therapy. 3.teeth which had to be extracted to orthodontic treatment plan in close future but also had tobe treated due to deep caries. 4.patient willfulness. Exclusion criteria: 1. Teeth in which there is inflammation at the exposure site, or bleeding in an amount for a hyperemic or inflamed pulp 2. Necrotic or infectious pulps 3. Carious exposures.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Hard tissue formation. Timepoint: After 6-9 months as part of the orthodontic treatment. Method of measurement: Microscopic view.	—

Secondary

Measure	Time frame
Pulp inflammaetion. Timepoint: After 6-9 months as part of the orthodontic treatment. Method of measurement: Microscopic view.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Naser Asl Aminabadi

Tabriz University of Medical Sciences

n-aminabadi@tbzmed.ac.ir+98 41 1335 5965

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026