The effects of cinnamon on lipid profile, liver enzymes,insulin resistance and hs-CRP inflammatory factor, in patients with Nonalcoholic Steatohepatitis

The effects of cinnamon on lipid profile, liver enzymes, insulin resistance and hs-CRP inflammatory factor, in patients with Nonalcoholic Steatohepatitis

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201207114010N9

Enrollment

Registered

2013-01-11

Start date

2012-09-05

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonalcoholic steatohepatitis (NASH). Nonalcoholic steatohepatitis (NASH)

Interventions

Intervention 1: Intervention: 4cinnamon capsules daily for 3 months. Intervention 2: Control: 4 placebo capsule (wheat flour) daily for 3 months.

Treatment - Drugs

Placebo

Intervention: 4cinnamon capsules daily for 3 months

Control: 4 placebo capsule (wheat flour) daily for 3 months

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age, 18 - 65 years old; Abnormal serum transferase (ALT & AST more than 1/5 fold of normal range); Sonographic findings compatible with hepatic steatosis (degree 1 or more); NASH was diagnosed during previous 6 months; no history of alcohol consumption; absence of Pregnancy, lactation, and Professional athletic; absence of other hepatobiliary disorders, autoimmune disease, malignancies, and endocrine disorders; absence of taking any medications in last 3 months. Exclusion criteria: Evidence of any allergic reaction to cinnamon; pregnancy; disliking to continue study with any reason.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Hs-CRP. Timepoint: at the beginning and at the last. Method of measurement: ELISA.;Cholestrol, TG, LDL-c, HDL-c. Timepoint: at the beginning and at the last. Method of measurement: Biochemistry.;ALT, AST, GGT. Timepoint: at the beginning and at the last. Method of measurement: Biochemistry.;FBS. Timepoint: at the beginning and at the last. Method of measurement: Biochemistry.;Insulin. Timepoint: at the beginning and at the last. Method of measurement: elaisa.;Insulin resistance. Timepoint: at the beginning and at the last. Method of measurement: formula.	—

Measure

Time frame

Hs-CRP. Timepoint: at the beginning and at the last. Method of measurement: ELISA.;Cholestrol, TG, LDL-c, HDL-c. Timepoint: at the beginning and at the last. Method of measurement: Biochemistry.;ALT, AST, GGT. Timepoint: at the beginning and at the last. Method of measurement: Biochemistry.;FBS. Timepoint: at the beginning and at the last. Method of measurement: Biochemistry.;Insulin. Timepoint: at the beginning and at the last. Method of measurement: elaisa.;Insulin resistance. Timepoint: at the beginning and at the last. Method of measurement: formula.

—

Secondary

Measure	Time frame
Waist circumference. Timepoint: at the beginning and at the last. Method of measurement: non stretch meter.;Weight and BMI. Timepoint: at the beginning and at the last. Method of measurement: Weight will be measured by Secca scale , BMI by formula.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Azita Hekmatdoost

National Nutrition and Food Technology Research Institute (NNFTRI)

a_hekmat2000@yahoo.com

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026