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Evaluating the Effects of Iatrogenic Endometrial Injury before Performing Intrauterine insemination

Evaluating the Effects of Iatrogenic Endometrial Injury before Performing Intrauterine Insemination in Increasing Fertility in Couples Referred to infertility center

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2012070810210N1
Enrollment
144
Registered
2013-01-12
Start date
2011-03-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility and treatment methods. Female infertility, unspecified

Interventions

Intervention 1: Group A undergo endometrial biopsy, by a Novak curret biopsy catheter (Neuilly-en-Thelle, France between days 6–8 of previous menstrual cycle before IUI (n=72) and group B (n=72) under
Treatment - Other
Group A undergo endometrial biopsy, by a Novak curret biopsy catheter (Neuilly-en-Thelle, France between days 6–8 of previous menstrual cycle before IUI (n=72) and group B (n=72) underwent IUI cycles

Sponsors

Shiraz university of medical sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 18–40 years old patients who suffered from unexplained infertility, mild male factor and mild endometriosis; All women had normal plasma concentrations of day 3 LH and FSH; normal tests of renal and hepatic function; normal complete blood counts; normal HSG, laparoscopy and hysteroscopy and negative pregnancy tests. When the endometriosis was diagnosed, the stage was determined according to the revised American society for reproductive medicine classification and the score was recorded. Only those with mild endometriosis were included in the study while those with moderate to severe endometriosis were excluded from the study. Exclusion criteria: hirsutism; autoimmune disorders; endocrinopathies; cirrhosis and other chronic liver diseases; cigarette smoker and/or alcohol abuser (each of the partner); ovarian hyperstimulation syndrome (OHSS ); no desire to continue the program.

Exclusion criteria

Exclusion criteria:

Design outcomes

Secondary

MeasureTime frame
Clinical pregnancy. Timepoint: 4 weeks after the missed period. Method of measurement: detecting of intrauterine sac by vaginal sonography.

Primary

MeasureTime frame
Pregnancy. Timepoint: two weeks after the missed period. Method of measurement: measuring level of blood BhCG by ELISA.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. afsun Zarei

Shiraz university of medical sciences

zareia@sums.ac.ir+98 71 1233 2365

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026