Mild to moderate acne vulgaris. acne vulgaris
Conditions
Interventions
Intervention 1: Tretioin cream once a day (at night) and Aloe vera gel 50% (twice in day). Intervention 2: Tretinoin cream once a day (at night) and Placebo (twice in day) for 8 weeks.
Treatment - Drugs
Placebo
Tretioin cream once a day (at night) and Aloe vera gel 50% (twice in day)
Tretinoin cream once a day (at night) and Placebo (twice in day) for 8 weeks
Sponsors
Chancellor of Research, Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
11 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:the score of acne was determined based on GAGS scale and patients with mild to moderate acne vulgaris enter to study; and a urinary pregnancy test was performed; the cases have not received any medication. Exclusion criteria: Patients with an uncontrolled systemic disease; patients had received topical antiacne therapy two months before or during the study or any systemic therapy with antibiotics 30 days before or during the study; were known to be allergic or sensitive to any of the study medications or their components; had previously been treated with systemic retinoids; or were pregnant, or planning to become pregnant, and lactating.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lesion count. Timepoint: 0, 2, 4, 8 th. week. Method of measurement: lesion scoring.;Adverse reactions (scaling, oedema, erythema, burning, and itching). Timepoint: 2, 4, 8 th. week. Method of measurement: observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMajid Saeedi
Department of pharmaceutics
Outcome results
None listed