Acute kidney injury (AKI) refers to an abrupt decrease in kidney function, resulting in the retention of urea and other nitrogenous waste products and in the dysregulation of extracellular volume and electrolytes. Acute kidney injury
Conditions
Interventions
Intervention 1: Control group : patients with serum CPK level higher than 1000 I.U, no intervention, just observational. Intervention 2: Intervention group: : patients with serum CPK level>1000 I.U,
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: patients over 18 patients with at least two distinct injuries who were diagnosed with multiple trauma Serum creatinine phosphate level higher than or equal to 5 times normal, from admission to the intensive care unit up to 48 hours later
Exclusion criteria
Exclusion criteria: Patients with a recent history of myocardial infarction (within one week before the trauma) pregnancy or lactation, patients with direct kidney trauma high serum vitamin D3 levels patients who received more than 2000I.U of vitamin D3 per day during the past week, total calcium level above 9 mg/dl or phosphate level above 6 mg/dl at the time of admission, history of organ transplantation or long-term use of immunosuppressive drugs, patients with a history of diseases related to vitamin D3 levels, such as primary parathyroid, metabolic bone disease, or acute renal failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of acute kidney injurie. Timepoint: within 2 weeks if ICU admission. Method of measurement: laboratory results of Serum creatinine; urine output.;Serum creatine phosphokinase level. Timepoint: Daily from the ICU admission date up to either reaching normal level or 14 days. Method of measurement: Serum CPK level laboratory measurement kits. | — |
Secondary
| Measure | Time frame |
|---|---|
| Follow up death for 28 days. Timepoint: since admitted it the ICU we follow up daily up to 28 days. Method of measurement: dead or alive before the 28 days follow up. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Sistanizad
Shahid Beheshti University of Medical Sciences
Outcome results
None listed