Diseases of the nervous system injury. Diffuse traumatic brain injury
Conditions
Interventions
Intervention 1: Intervention group: Prescribing protein (1.5-2 mg/kg/day) for 5 days. Intervention 2: Control group: Prescribing a regular diet in the intensive care unit for 5 days.
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients older than 16 years old who have one of the following factors and stay in ICU for 5 days. Subarachnoid Hemorrhage Subdural Hematoma Traumatic brain injury Aneurysm Intracranial hemorrhage Others
Exclusion criteria
Exclusion criteria: Patient's death during the first three days of study Patient dis-admit with personal satisfaction within the first three days Disapprove of the patient to enter the research Contraindication of receiving high protein die Hepatic encephalopathy An allergy to the drug Consumer of Warfarin Pregnancy Metabolic disorders (gout, phenylketonuria) Chronic renal failure Proteinuria is higher than 3 grams per day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuron Specific Enolase. Timepoint: At the beginning of the intervention (before the intervention) and 3 and 5 days after the beginning of the intervention. Method of measurement: Enolase CanAg kit.;Serum Transtreatin Level. Timepoint: At the beginning of the intervention (before the intervention) and 3 and 5 days after the beginning of the intervention. Method of measurement: Prealbumin Minineph *25T.;Nitrogen Balance. Timepoint: At the beginning of the intervention (before the intervention) and 5 days after the beginning of the intervention. Method of measurement: Based on urea concentration. | — |
Secondary
| Measure | Time frame |
|---|---|
| Extended Glasgow Outcome Scale. Timepoint: The end of the first, second and third months after the begining intervention. Method of measurement: Score of Extended Glasgow Outcome Scale.;Mortality. Timepoint: The end of the first, second and third months after the begining intervention. Method of measurement: Will be checked by phone.;Effect of medication on neuron specific Enolase. Timepoint: At the beginning of the intervention (before the intervention) and 3 and 5 days after the beginning of the intervention. Method of measurement: Blood sample.;Effect of medication on serum prealbumin level. Timepoint: At the beginning of the intervention (before the intervention) and 3 and 5 days after the beginning of the intervention. Method of measurement: blood sample.;Effect of medication on nitrogen balance. Timepoint: At the beginning of the intervention (before the intervention) and 5 days after the beginning of the intervention. Method of measurement: Urine sample. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Sistanizad
Shahid Beheshti University of Medical Sciences
Outcome results
None listed