menopausal symptoms. Other obstetric conditions, not elsewhere classified
Conditions
Interventions
The intervention group will receive daily 3 capsules containing 500 mg of powdered Cornus mas for 4 weeks. Placebo group will receive daily 3 capsules containing 500 mg starch powder for 4 weeks..
Treatment - Drugs
The intervention group will receive daily 3 capsules containing 500 mg of powdered Cornus mas for 4 weeks. Placebo group will receive daily 3 capsules containing 500 mg starch powder for 4 weeks.
Sponsors
Vice-chancellor for research, Iran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for intervention: Age 60-45 years; Amenorrhea for at least 12 months; Having at least 3 times in hot flushing medium during 24 hours and at least 2 weeks before study; Lack of history of allergy to Cornus mas use and its products; Not receiving hormone replacement therapy within 6 months; At present not use of estrogen and Medroxyprogestrone; Lack of effective drugs on hot flashes, such as clonidine, methyldopa, , veralpereid, naloxone and Tibolone; Lack of vaginal bleeding of unknown origin; Have not active liver disease and renal failure; No history of malignancy; No history of thromboembolism; Willingness to participate in the study. Exclusion criteria of intervention: Vegetarian diet; Soya consumption; Cornus mas consumption; Regular use of vitamin; Smoking; take antibiotics ; Unwillingness to continue Cornus mas consumption.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Menopausal symptoms, some inflammatory and bone markers, body fat percent. Timepoint: Ten days before the intervention- Beginning of the second ten days of study- For ten days in the third and fourth and fifth of the study. Method of measurement: Kupperman menopausal index, Bio-Chemical testing, Bioelectrical Impedance Analysis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Abdominal pain? diarrhea. Timepoint: Once every ten days. Method of measurement: By interview. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahnaz Rimaz
Iran University of Medical Sciences
Outcome results
None listed